INT206746

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.15
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (TPM1) cytosol (TPM1) cytoskeleton (TPM1)
cytoskeleton organization (TPM1) cytoplasm (TPM1)
Anatomy Link Frequency
Uterus 1
stromal cells 1
lumen 1
TPM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 96.72 Very High Very High Very High
agonist 2 96.12 Very High Very High Very High
Dismenorea 1 77.04 Quite High
Neuropeptide 1 75.12 Quite High
imagery 64 5.00 Very Low Very Low Very Low
Action potential 33 5.00 Very Low Very Low Very Low
ischemia 14 5.00 Very Low Very Low Very Low
isoflurane 13 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 14 100.00 Very High Very High Very High
Cancer 181 98.08 Very High Very High Very High
Nasopharynx Cancer 5 94.32 High High
Prostate Cancer 55 93.28 High High
Disease 22 92.20 High High
Metastasis 54 90.88 High High
Vascular Malformations 1 89.40 High High
Recurrence 5 84.60 Quite High
Telangiectasia 4 83.92 Quite High
Apoptosis 46 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time, we observe substantial increases in expression of 1,012 genes, including cardiac structural genes such as tropomyosin 1 and 2 (TPM1, 2, ?
Gene_expression (expression) of tropomyosin 1
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.07 Pain Relevance 0
At the same time, we observe substantial increases in expression of 1,012 genes, including cardiac structural genes such as tropomyosin 1 and 2 (TPM1, 2, ?
Gene_expression (genes) of tropomyosin 1
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.07 Pain Relevance 0
At the same time, we observe substantial increases in expression of 1,012 genes, including cardiac structural genes such as tropomyosin 1 and 2 (TPM1, 2, ?
Gene_expression (expression) of tropomyosin 1
3) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.07 Pain Relevance 0
Analyzed by peptide fragment matching and MS/MS, cisplatin caused notably increase expressions of some proteins in ovarian cancer, including tropomyosin family, actin family, triosephosphate isomerase family, and Hsp60, while expressions of some proteins in the enolase family decreased.
Gene_expression (expressions) of tropomyosin associated with ovarian cancer
4) Confidence 0.58 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.11 Pain Relevance 0
Differential expression analysis of the metastatic and primary tumor samples shows that a large number of the most highly downregulated genes such as TAGLN, ACTG2, TPM1, MYH111 and DES have been previously identified as expressed mostly in the prostatic stromal cells [15].
Gene_expression (expressed) of TPM1 in stromal cells associated with cancer
5) Confidence 0.35 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.52 Pain Relevance 0
In addition, NO-induced contraction and relaxation of pericytes may regulate lumen size and thereby control capillary perfusion [32], functions supported by pericyte expression of the muscle isoforms of actin, myosin and tropomyosin [7].
Gene_expression (expression) of tropomyosin in lumen
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.22 Pain Relevance 0
Uterus SMCs also have especially high expression levels of many genes that encode the contractile machinery of SMCs, including tropomyosin 1 and 2, calponin, caldesmon 1, SM-?
Gene_expression (expression) of tropomyosin 1 in Uterus
7) Confidence 0.16 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.08 Pain Relevance 0.21

General Comments

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