INT20676

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 10.59
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ctse) peptidase activity (Ctse)
Anatomy Link Frequency
CEA 3
pancreas 2
stomach 2
lateral 1
CEA 1
Ctse (Rattus norvegicus)
Ctse - A2M (1)
Pain Link Frequency Relevance Heat
amygdala 134 100.00 Very High Very High Very High
Enkephalin 9 99.84 Very High Very High Very High
Dynorphin 4 99.84 Very High Very High Very High
Nicotine 8 99.46 Very High Very High Very High
Chronic pancreatitis 27 98.72 Very High Very High Very High
Anterior cingulate cortex 78 96.64 Very High Very High Very High
gABA 26 96.56 Very High Very High Very High
Dopamine 146 95.80 Very High Very High Very High
Pain 4 95.20 Very High Very High Very High
Glutamate 135 93.68 High High
Disease Link Frequency Relevance Heat
Hyperplasia 36 99.92 Very High Very High Very High
Anxiety Disorder 294 99.54 Very High Very High Very High
Adenoma 18 99.20 Very High Very High Very High
Cancer 27 99.00 Very High Very High Very High
Adenocarcinoma 45 98.96 Very High Very High Very High
Pancreatitis 27 98.72 Very High Very High Very High
Whiplash Injuries 5 97.20 Very High Very High Very High
Stress 20 88.00 High High
Ulcers 2 87.44 High High
Injury 114 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings suggest that the expression of CTSE is associated with the pathogenesis of pancreatic ductal adenocarcinoma, that CTSE in the pancreatic juice seems to be a useful marker for a definitive diagnosis and that CTSE may be expressed at a relatively early stage of multistep carcinogenesis in pancreatic lesions.
Gene_expression (expressed) of CTSE associated with adenocarcinoma
1) Confidence 0.77 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 1.18 Pain Relevance 0.23
Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report.
Gene_expression (Expression) of cathepsin E in pancreas associated with cancer
2) Confidence 0.77 Published 1996 Journal Int. J. Cancer Section Title Doc Link 8759606 Disease Relevance 0.78 Pain Relevance 0.07
CTSE was also expressed in mucin-producing adenoma, intraductal papillary hyperplasia and mucinous hyperplasia.
Gene_expression (expressed) of CTSE associated with adenoma and hyperplasia
3) Confidence 0.77 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 1.31 Pain Relevance 0.22
Our findings suggest that the expression of CTSE is associated with the pathogenesis of pancreatic ductal adenocarcinoma, that CTSE in the pancreatic juice seems to be a useful marker for a definitive diagnosis and that CTSE may be expressed at a relatively early stage of multistep carcinogenesis in pancreatic lesions.
Gene_expression (expression) of CTSE associated with adenocarcinoma
4) Confidence 0.77 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 1.29 Pain Relevance 0.25
Pancreatic juice was collected from the patients and subjected to sandwich ELISA and Western analysis for detecting CTSE.
Gene_expression (detecting) of CTSE
5) Confidence 0.67 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 1.24 Pain Relevance 0.21
SIGNIFICANCE: The results suggest that GABA-A receptor mechanism of the CeA may influence morphine state-dependent memory.


Gene_expression (mechanism) of CeA in CeA
6) Confidence 0.65 Published 2010 Journal Life Sci. Section Body Doc Link 20403365 Disease Relevance 0 Pain Relevance 0
In contrast, there was no significant nicotine-induced increase in c-fos expression in CEA CRF or DYN cells, whereas nicotine treatment did increase c-fos expression within CEA ENK cells.
Gene_expression (expression) of CEA CRF in CEA associated with dynorphin, nicotine, enkephalin and amygdala
7) Confidence 0.63 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16739166 Disease Relevance 0.07 Pain Relevance 1.07
Cathepsin E (CTSE) is a non-secretory, intracellular, but non-lysosomal proteinase found in the highest concentration in the superficial epithelial cells of the stomach.
Gene_expression (found) of CTSE in stomach
8) Confidence 0.60 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 0.45 Pain Relevance 0.07
Cathepsin E (CTSE) is a non-secretory, intracellular, but non-lysosomal proteinase found in the highest concentration in the superficial epithelial cells of the stomach.
Gene_expression (found) of Cathepsin E in stomach
9) Confidence 0.60 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 0.45 Pain Relevance 0.07
The aims of our study were to examine the expression of CTSE in the pancreas, to establish an assay system of CTSE and to evaluate the diagnostic usefulness of CTSE in the pancreatic juice.
Spec (examine) Gene_expression (expression) of CTSE in pancreas
10) Confidence 0.60 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 0.55 Pain Relevance 0.08
The text can be found on http://www.svv.ch CEA-study.1
Gene_expression (found) of CEA
11) Confidence 0.56 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2556470 Disease Relevance 0.79 Pain Relevance 0.10
Intra-amygdalar (i/am) microinjections of the enkephalin analog, (D-Ala2)-Met-enkephalinamide (DAME, 3, 10 and 30 micrograms) into the central amygdalar nucleus (CEA) produced a dose-related, naltrexone-reversible attenuation of cold restraint (3 h at 4 degrees C)-induced gastric mucosal lesions in rats.
Gene_expression (produced) of CEA (A2M) in CEA associated with enkephalin
12) Confidence 0.53 Published 1990 Journal Behav. Brain Res. Section Abstract Doc Link 2154234 Disease Relevance 0.33 Pain Relevance 0.29
CTSE in the pancreatic juice was present in 8 of 11 patients with pancreatic ductal adenocarcinoma, 5 of 10 patients with mucin-producing tumor, 1 of 3 patients with intraductal papillary hyperplasia and 4 of 43 patients with chronic pancreatitis.
Gene_expression (present) of CTSE associated with adenocarcinoma, cancer, chronic pancreatitis and hyperplasia
13) Confidence 0.52 Published 1996 Journal Int. J. Cancer Section Abstract Doc Link 8759606 Disease Relevance 1.43 Pain Relevance 0.25
Areas included in the cFos analysis were: the paraventricular nucleus (PVN), CEA, BLA (subdivided into anterior and posterior nuclei) and lateral nucleus of the amygdala, Nacc (core and shell), and ACC.
Gene_expression (nucleus) of CEA in lateral associated with anterior cingulate cortex and amygdala
14) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0 Pain Relevance 0.14
0.002), CEA (F4, 43?
Gene_expression (0.002) of CEA
15) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.32 Pain Relevance 0.38
In terms of cFos expression, fear conditioning elevates expression in the BLA, but not the CEA.
Gene_expression (expression) of CEA associated with anxiety disorder
16) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137950 Disease Relevance 0.40 Pain Relevance 0.74
In both "home" and "novel" amphetamine groups, c-fos mRNA in the BSTov and CEA was predominantly expressed in enkephalin-containing cells; coexpression with corticotropin-releasing hormone was rare.
Gene_expression (expressed) of CEA in CEA associated with enkephalin and amygdala
17) Confidence 0.29 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11160452 Disease Relevance 0 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox