INT206768

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 5.83
Pain Relevance 10.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
spinal 1
spinal cord 1
synapses 1
TP53 (Homo sapiens)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 457 100.00 Very High Very High Very High
c fibre 250 100.00 Very High Very High Very High
Kinase C 106 99.44 Very High Very High Very High
nMDA receptor 90 99.04 Very High Very High Very High
Spinal cord 146 99.02 Very High Very High Very High
qutenza 17 98.88 Very High Very High Very High
nMDA receptor antagonist 8 96.08 Very High Very High Very High
Sciatic nerve 64 94.56 High High
depression 54 94.52 High High
spinal dorsal horn 29 92.80 High High
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 202 100.00 Very High Very High Very High
Depression 54 94.52 High High
Neuropathic Pain 39 89.88 High High
Pain 80 89.44 High High
Hyperalgesia 135 89.32 High High
Inflammatory Pain 8 85.92 High High
Wound Healing 8 83.32 Quite High
Injury 26 82.64 Quite High
INFLAMMATION 28 82.32 Quite High
Nervous System Injury 16 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At least some of the C-fibre synapses are apparently unique in that LTP can be induced by LFS and by natural, low or high frequency, asynchronous and irregular discharge patterns in sensory nerve fibres.
LFS Positive_regulation (induced) of LTP in synapses associated with c fibre, li-fraumeni syndrome and long-term potentiation
1) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1852298 Disease Relevance 0.45 Pain Relevance 1.24
M) completely prevented induction of LTP by LFS (Fig. 2D; Table 1).
LFS Positive_regulation (induction) of LTP associated with li-fraumeni syndrome and long-term potentiation
2) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.66 Pain Relevance 1.16
And indeed, LFS-induced LTP required activation of NMDA receptors, as blockade of spinal NMDA receptors with the competitive NMDA receptor antagonist D-AP5 (100 ?
LFS Positive_regulation (induced) of LTP in spinal associated with nmda receptor antagonist, li-fraumeni syndrome, nmda receptor and long-term potentiation
3) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.78 Pain Relevance 1.59
LFS-induced mean LTP of C-fibre evoked field potentials to 160% ± 13% of control (p < 0.05, n = 5) at 60 min after conditioning stimulation (Fig 1B; Table 1).
LFS Positive_regulation (induced) of LTP associated with c fibre, li-fraumeni syndrome and long-term potentiation
4) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.31 Pain Relevance 0.80
M) abolished induction of LTP by LFS in all animals tested (Fig. 2E; Table 1).
LFS Positive_regulation (induction) of LTP associated with li-fraumeni syndrome and long-term potentiation
5) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.95 Pain Relevance 1.68
We have recently discovered that in a spinal cord slice preparation with long dorsal roots intact LFS of dorsal roots at C-fibre intensity induces LTP which involves a rise in postsynaptic [Ca2+]i and Ca2+-dependent signal transduction pathways [4].
LFS Positive_regulation (induces) of LTP in spinal cord associated with c fibre, li-fraumeni syndrome, long-term potentiation and spinal cord
6) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.96 Pain Relevance 0.96
We have shown previously that in vitro LFS-induced LTP requires a rise in [Ca2+]i [4].
LFS Positive_regulation (induced) of LTP associated with li-fraumeni syndrome and long-term potentiation
7) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.46 Pain Relevance 0.81
We found that the signal transduction pathways causing LFS-induced LTP in vivo include activation of neurokinin 1 and N-methyl-D-aspartate receptors, rise of [Ca2+]i from intracellular stores and via T-type voltage-dependent Ca2+ channels, activation of phospholipase C, protein kinase C and Ca2+-calmodulin dependent kinase II.
LFS Positive_regulation (induced) of LTP associated with kinase c, li-fraumeni syndrome, nmda receptor and long-term potentiation
8) Confidence 0.00 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2424039 Disease Relevance 0.68 Pain Relevance 1.22
On the other hand, we have shown recently that in the intact animal, LTP can be induced by LFS as well as by subcutaneous capsaicin or formalin injections also [4].
LFS Positive_regulation (induced) of LTP associated with li-fraumeni syndrome, qutenza and long-term potentiation
9) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.57 Pain Relevance 0.74

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