INT206803

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.78
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
HGF 4
platelets 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 84.84 Quite High
Inflammation 11 82.24 Quite High
GABAergic 10 74.56 Quite High
ischemia 10 49.52 Quite Low
addiction 14 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 24 99.78 Very High Very High Very High
Pancreatitis 64 98.06 Very High Very High Very High
INFLAMMATION 13 84.48 Quite High
Pressure And Volume Under Development 6 82.52 Quite High
Neurological Disease 2 80.40 Quite High
Adhesions 19 61.92 Quite High
Apoptosis 6 54.96 Quite High
Cv Unclassified Under Development 10 49.52 Quite Low
Peripheral Arterial Disease 4 45.76 Quite Low
Myocardial Infarction 4 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate that BDNF-induced TrkB activation and calcium entry via TRPC are both required for BDNF transcription effects.
Positive_regulation (induced) of Positive_regulation (activation) of TrkB
1) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.08 Pain Relevance 0.04
The results demonstrate that BDNF-induced TrkB activation and calcium entry via TRPC are both required for BDNF transcription effects.
Positive_regulation (required) of Positive_regulation (activation) of TrkB
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.08 Pain Relevance 0.04
It is well known that the inhibition of certain coagulatory steps, e.g., by applying hemodiluting or anticoagulatory substances, improves the outcome of AP.16,17 Coagulation and hemostasis comprise two interacting pathways: humoral coagulatory factors leading to the activation of fibrinogen as the final step of the coagulation cascade and cellular factors, which are represented by activated platelets.
Positive_regulation (leading) of Positive_regulation (activation) of factors in platelets associated with pancreatitis
3) Confidence 0.01 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852387 Disease Relevance 0.78 Pain Relevance 0.16
Indeed, hypoxia (1.5% O2) induced a significant increase in accumulation of selected factors like Angiogenin, HGF, IL-8, PDGF-BB, SDF-1 and VEGF-A in the EPC conditioned media compared to normoxia (P<0.05; Table 1).
Positive_regulation (increase) of Positive_regulation (accumulation) of factors in HGF associated with hypoxia
4) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0
Indeed, hypoxia (1.5% O2) induced a significant increase in accumulation of selected factors like Angiogenin, HGF, IL-8, PDGF-BB, SDF-1 and VEGF-A in the EPC conditioned media compared to normoxia (P<0.05; Table 1).
Positive_regulation (induced) of Positive_regulation (accumulation) of factors in HGF associated with hypoxia
5) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0

General Comments

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