INT206816

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.06
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Muc2) nucleus (Muc2) cytoplasm (Muc2)
Anatomy Link Frequency
bands 1
epithelium 1
respiratory 1
Muc2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 28 85.68 High High
Inflammation 100 74.72 Quite High
Inflammatory mediators 6 6.40 Low Low
imagery 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Piles 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 32 99.56 Very High Very High Very High
Respiratory Disease 3 99.12 Very High Very High Very High
Colitis 37 85.84 High High
Cystic Fibrosis 28 85.68 High High
Pulmonary Disease 12 85.24 High High
INFLAMMATION 104 74.72 Quite High
Status Asthmaticus 3 71.28 Quite High
Malignant Neoplastic Disease 3 68.64 Quite High
Cyst 11 52.48 Quite High
Ovarian Cysts 5 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteomic analysis of these bands as performed previously did not reveal any alterations in the Muc2 peptide coverage or other major proteins (not shown) [2].
Regulation (alterations) of Muc2 in bands
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.06 Pain Relevance 0.03
Two mucins, MUC5AC and MUC5B, have been convincingly demonstrated to be the major components of the crude mucus gel lining the respiratory tract 10, whilst an up-regulation of MUC2 has been reported in respiratory disease 11.
Regulation (regulation) of MUC2 in respiratory associated with respiratory disease
2) Confidence 0.36 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.36 Pain Relevance 0
These experiments suggest that the epithelium is normal and that there were no major biochemical alterations in the Muc2 mucin at these early time points of DSS treatment.


Neg (no) Regulation (alterations) of Muc2 mucin in epithelium
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.07 Pain Relevance 0.04
Many studies have focused on MUC5AC and MUC2 regulation in airway diseases using mainly airway cell and explant cultures [32-34] while the expression of the oligomeric mucin MUC5B and the membrane-bound mucin MUC4 have not yet been investigated.
Regulation (regulation) of MUC2 associated with disease
4) Confidence 0.24 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.34 Pain Relevance 0.04
While many studies have focused on gene regulation of both MUC2 and MUC5AC using mainly airway cell cultures and explants, regulation of MUC4 and MUC5B in airway diseases have been ignored to date.
Regulation (regulation) of MUC2 associated with disease
5) Confidence 0.24 Published 2007 Journal Respir Res Section Body Doc Link PMC1899493 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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