INT206820

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 23
Disease Relevance 13.48
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Muc1) nucleus (Muc1) cytoplasm (Muc1)
Anatomy Link Frequency
respiratory 9
pancreas 2
ovary 2
colon 1
epithelium 1
Muc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 95.00 High High
Inflammation 16 94.96 High High
imagery 103 82.88 Quite High
addiction 7 39.96 Quite Low
ketamine 7 26.72 Quite Low
anesthesia 9 25.52 Quite Low
Pain 14 8.48 Low Low
isoflurane 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 228 100.00 Very High Very High Very High
Teratoma 210 99.98 Very High Very High Very High
Disease 6 98.88 Very High Very High Very High
Targeted Disruption 9 98.40 Very High Very High Very High
Injury 67 97.68 Very High Very High Very High
Malignant Neoplastic Disease 42 97.28 Very High Very High Very High
Colitis 14 97.04 Very High Very High Very High
Pancreatitis 10 95.00 High High
INFLAMMATION 18 94.96 High High
Pancreatic Cancer 94 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the healthy lung, MUC1 and MUC4 are expressed on the apical surface of the respiratory epithelium.
Gene_expression (expressed) of MUC1 in epithelium
1) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.71 Pain Relevance 0.05
In the present smoke inhalation mouse model, we observed no difference in MUC1 and MUC4 protein expression between mice in the control and smoke inhalation groups (Figure 2).
Gene_expression (expression) of MUC1
2) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0 Pain Relevance 0
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (expression) of MUC1
3) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6 whilst MUC5AC was expressed in both components.
Gene_expression (expressed) of MUC1 in respiratory associated with teratoma
4) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.86 Pain Relevance 0
MUC1 and MUC1c were expressed exclusively in respiratory epithelium, MUC2 and some MUC6 (focal) in the colonic tissue and MUC5AC in both tissues.
Gene_expression (expressed) of MUC1 in respiratory
5) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.51 Pain Relevance 0
The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6 whilst MUC5AC was expressed in both components.
Gene_expression (expressed) of MUC1c in respiratory associated with teratoma
6) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.86 Pain Relevance 0
The expression of MUC1 and MUC1c in the respiratory epithelium of the tissue raises interesting questions.
Gene_expression (expression) of MUC1 in respiratory
7) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.67 Pain Relevance 0
MUC1 has long been known to be a prognostic factor in various cancers and is highly expressed in cancers of the breast, ovary, pancreas and colon 15, 29-31.
Gene_expression (expressed) of MUC1 in colon associated with cancer
8) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.87 Pain Relevance 0
MUC1 and MUC1c were expressed exclusively in respiratory epithelium, MUC2 and some MUC6 (focal) in the colonic tissue and MUC5AC in both tissues.
Gene_expression (expressed) of MUC1c in respiratory
9) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.51 Pain Relevance 0
The expression of MUC1 and MUC1c in the respiratory epithelium of the tissue raises interesting questions.
Gene_expression (expression) of MUC1c in respiratory
10) Confidence 0.54 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.67 Pain Relevance 0
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (performed) of MUC1
11) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.07 Pain Relevance 0
For determination of MUC1, MUC4, MUC5AC, and JNK protein expression, Western blot analysis was performed with MUC1 (Abcam, Cambridge, UK), MUC 4 (Invitrogen, Carlsbad, California), MUC 5AC antibody and JNK antibodies (Santa Cruz Biotechnology, Santa Cruz, CA, and Cell Signaling Technology, Beverly, MA).
Gene_expression (antibodies) of MUC1
12) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.12 Pain Relevance 0
Therefore we suggest that ELISA measurements of serum HIP/HAP and MUC-1 levels could be added to a panel of tests for the routine screening of population to identify individuals at increased risk for the developing pancreatic carcinoma.
Gene_expression (levels) of MUC-1 associated with pancreatic cancer
13) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 0.97 Pain Relevance 0.21
A positive correlation was observed for mean concentration of MUC-1 in the serum with stage of disease.
Gene_expression (concentration) of MUC-1 associated with disease
14) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 0.87 Pain Relevance 0.07
MUC1 was the first reported membraneĀ–bound mucin, widely expressed by normal glandular epithelial cells and dramatically increased in malignant cells of the breast, ovary and pancreas 15.
Gene_expression (expressed) of MUC1 in pancreas associated with malignant neoplastic disease
15) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.44 Pain Relevance 0
Smoke exposure did not alter the expression of MUC1 and MUC4 proteins in all 3 groups compared with control.


Gene_expression (expression) of MUC1
16) Confidence 0.46 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3014901 Disease Relevance 0.51 Pain Relevance 0
The membrane-associated mucins, MUC1 and MUC4, were found to be highly expressed in both the control and smoke inhalation group mice.
Gene_expression (expressed) of MUC1
17) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.44 Pain Relevance 0.03
The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6.
Gene_expression (expressed) of MUC1 in respiratory associated with teratoma
18) Confidence 0.42 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.49 Pain Relevance 0
The respiratory component of the teratoma expressed MUC1 and MUC1c and the colonic components of the teratoma expressed MUC2 and some MUC6.
Gene_expression (expressed) of MUC1c in respiratory associated with teratoma
19) Confidence 0.42 Published 2007 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1852400 Disease Relevance 0.49 Pain Relevance 0
The tissue showed colonic and respiratory elements, expressed mainly acidic mucin of the sulphated type, in the form of MUC1 MUC1c, MUC2 and lesser MUC5AC and MUC6.



Gene_expression (expressed) of MUC1c in respiratory
20) Confidence 0.19 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 1.17 Pain Relevance 0

General Comments

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