INT206821

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.85
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

proteinaceous extracellular matrix (Muc2) nucleus (Muc2) cytoplasm (Muc2)
Anatomy Link Frequency
colon 2
Lung 1
small intestine 1
respiratory 1
Muc2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 95.12 Very High Very High Very High
Inflammation 95 94.72 High High
Inflammatory mediators 5 90.12 High High
fibrosis 14 62.68 Quite High
Crohn's disease 18 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Piles 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 37 99.76 Very High Very High Very High
Respiratory Disease 2 99.12 Very High Very High Very High
INFLAMMATION 97 94.72 High High
Hemophilus Infection 89 92.12 High High
Skin Cancer 1 89.52 High High
Colitis 37 85.84 High High
Bacterial Respiratory Disease 6 85.56 High High
Disease 45 83.88 Quite High
Malignant Neoplastic Disease 3 68.64 Quite High
Targeted Disruption 12 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is thus likely that the highly sulfated DSS is readily soluble in the highly sulfated MUC2 mucin network.
Positive_regulation (sulfated) of MUC2 mucin
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.05 Pain Relevance 0.03
The guanidinium chlorides soluble fraction contained the DSS that had accumulated in the distal colon in addition to some Muc2 (marked M).
Positive_regulation (accumulated) of Muc2 in colon
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0 Pain Relevance 0
Two mucins, MUC5AC and MUC5B, have been convincingly demonstrated to be the major components of the crude mucus gel lining the respiratory tract 10, whilst an up-regulation of MUC2 has been reported in respiratory disease 11.
Positive_regulation (regulation) of MUC2 in respiratory associated with respiratory disease
3) Confidence 0.37 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.36 Pain Relevance 0
As expected from the immunohistochemistry studies, expression of lysozyme was also strongly reduced in the small intestine as was the expression of the most abundant mucin, Muc 2, in both small intestine and colon (Fig. 7D).
Positive_regulation (abundant) of Muc 2 in colon
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.09 Pain Relevance 0
Lung infection induced an increase of the secreted gel-forming mucin Muc5b and a decrease of the membrane bound mucin Muc4.
Positive_regulation (increase) of gel-forming in Lung associated with infection
5) Confidence 0.36 Published 2007 Journal Respir Res Section Abstract Doc Link PMC1899493 Disease Relevance 1.19 Pain Relevance 0.27
, mucin MUC2 and TLR2 [15-19].
Positive_regulation (mucin) of MUC2
6) Confidence 0.22 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.08 Pain Relevance 0.14
As expected from the immunohistochemistry studies, expression of lysozyme was also strongly reduced in the small intestine as was the expression of the most abundant mucin, Muc 2, in both small intestine and colon (Fig. 7D).
Positive_regulation (abundant) of Muc 2 in small intestine
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.09 Pain Relevance 0

General Comments

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