INT206849

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.26
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ESR1, ALDH1A1) nucleoplasm (ESR1) small molecule metabolic process (ALDH1A1)
enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1)
Anatomy Link Frequency
uterine 2
ESR1 (Homo sapiens)
ALDH1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 78.76 Quite High
fibrosis 2 41.76 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
calcitonin gene related peptide 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 144 100.00 Very High Very High Very High
Rheumatoid Arthritis 46 100.00 Very High Very High Very High
Apoptosis 18 80.88 Quite High
Cancer 44 78.12 Quite High
Death 2 50.76 Quite High
Colon Cancer 2 45.72 Quite Low
Cirrhosis 2 41.76 Quite Low
Smooth Muscle Tumor 2 25.44 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Neuroblastoma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our integrated analysis of expression data collected by independent studies revealed that expression of two genes, ALDH1A1 and CRABP2 for RA synthesis or mobilization was differentially expressed in human uterine fibroids and regulated by estrogen in the rat uterus.
estrogen Regulation (regulated) of Gene_expression (expression) of ALDH1A1 in uterine associated with uterine fibroids and rheumatoid arthritis
1) Confidence 0.11 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.52 Pain Relevance 0.04
Lastly, estrogen affects retinoic acid (RA) synthesis and mobilization by regulating expression of CRABP2 and ALDH1A1.
estrogen Regulation (regulating) of Gene_expression (expression) of ALDH1A1 associated with rheumatoid arthritis
2) Confidence 0.05 Published 2007 Journal BMC Womens Health Section Abstract Doc Link PMC1852551 Disease Relevance 0.74 Pain Relevance 0

General Comments

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