INT206857

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.90
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Calcrl) aging (Calca) endoplasmic reticulum (Calcrl)
intracellular (Calca) signal transducer activity (Calcrl) cytoplasm (Calca)
Calca (Rattus norvegicus)
Calcrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 120 100.00 Very High Very High Very High
antagonist 44 100.00 Very High Very High Very High
calcitonin gene related peptide 2 100.00 Very High Very High Very High
Spinal cord 5 89.12 High High
nMDA receptor 19 85.92 High High
Pain 51 62.64 Quite High
amygdala 87 57.28 Quite High
nMDA receptor antagonist 6 42.80 Quite Low
Neuronal excitability 9 6.92 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 19 95.96 Very High Very High Very High
Cancer 66 93.80 High High
Uterine Fibroids 144 92.08 High High
Pain 50 62.64 Quite High
Stress 48 33.52 Quite Low
Nociception 4 12.12 Low Low
Starvation 10 8.88 Low Low
Rheumatoid Arthritis 54 5.00 Very Low Very Low Very Low
INFLAMMATION 29 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional CGRP1 receptors are formed by a heterodimeric complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) [69,70].
CGRP1 Binding (formed) of CRLR
1) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.12 Pain Relevance 0.71
Most interesting in this respect is the compound BIBN4096BS, a nonpeptide CGRP antagonist that acts at the extracellular interface of the RAMP-1–CLR protein interaction (635), already indicating a proof of principle.
CGRP Binding (interaction) of CLR associated with antagonist and calcitonin gene-related peptide
2) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.15
The calcitonin receptor-like receptor (CALCRL or CRLR), a G-protein coupled receptor, acts as a receptor for adrenomedullin (ADM) or calcitonin gene related peptide (CGRP) depending on which receptor activity modifying protein (RAMP) it partners with [47].
CGRP Binding (receptor) of calcitonin receptor-like receptor associated with calcitonin gene related peptide
3) Confidence 0.03 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.90 Pain Relevance 0.05
The calcitonin receptor-like receptor (CALCRL or CRLR), a G-protein coupled receptor, acts as a receptor for adrenomedullin (ADM) or calcitonin gene related peptide (CGRP) depending on which receptor activity modifying protein (RAMP) it partners with [47].
CGRP Binding (receptor) of CALCRL associated with calcitonin gene related peptide
4) Confidence 0.03 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.88 Pain Relevance 0.05

General Comments

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