INT206866

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.97
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SFRP1) extracellular space (SFRP1) extracellular region (SFRP1)
proteinaceous extracellular matrix (SFRP1) plasma membrane (SFRP1) intracellular (SFRP1)
Anatomy Link Frequency
neuronal 1
uterine 1
SFRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 20 53.04 Quite High
agonist 6 48.96 Quite Low
Neurotransmitter 6 23.84 Low Low
Pain 16 9.76 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
lumbar region 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Radiation Pneumonitis 72 100.00 Very High Very High Very High
Cancer 111 99.68 Very High Very High Very High
Uterine Fibroids 77 99.04 Very High Very High Very High
Endometroid Carcinoma 21 96.48 Very High Very High Very High
Fatigue 128 94.52 High High
Endometriosis (extended) 4 91.12 High High
Apoptosis 27 90.24 High High
Carcinoma 61 90.16 High High
Endometrial Cancer 153 87.68 High High
Pulmonary Disease 8 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FRP onset angle was increased in load conditions, whereas no significant effect of load was noted for FRP cessation angle.
Positive_regulation (increased) of FRP
1) Confidence 0.51 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.17 Pain Relevance 0.05
There was also a significant increase in FRP onset angle during loading conditions (Figure 4).
Positive_regulation (increase) of FRP
2) Confidence 0.51 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2259346 Disease Relevance 0.61 Pain Relevance 0
An augmented load led to increased FRP onset and cessation angles.
Positive_regulation (increased) of FRP
3) Confidence 0.47 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2850324 Disease Relevance 0 Pain Relevance 0
Westin and colleague [14] described that expression of estrogen-induced genes, RALDH2, EIG121, SFRP1, SFRP4, IGF-1, and IGF-IR, tend to be highest in the well-to-moderately differentiated endometrioid carcinoma.
Positive_regulation (induced) of SFRP1 associated with endometroid carcinoma
4) Confidence 0.35 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.98 Pain Relevance 0
Wnt signaling was recently implicated in the pathogenesis of uterine fibroids where the secreted frizzled related protein 1 (sFRP1) mRNA [10] was found to be significantly elevated in the tumor, and regulated by estrogen treatment.
Positive_regulation (elevated) of sFRP1 in uterine associated with uterine fibroids and cancer
5) Confidence 0.30 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.91 Pain Relevance 0
Analysing these results, we observed that genes implicated in neuronal differentiation of neuronal precursors, including SOCS2, sFRP1, amphiregulin, neuronal growth regulator 1 and EphA4, were also upregulated after neurogenic differentiation of BM-MSC [33-35].
Positive_regulation (upregulated) of sFRP1 in neuronal
6) Confidence 0.27 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0
Table 4 shows the association between the dosimetric Parameters (NTCP/V10) and the incidence of SARP for 94 patients; the incidences of SARP in the group with NTCP > 4.2% and NTCP ?
Positive_regulation (incidences) of SARP associated with radiation pneumonitis
7) Confidence 0.20 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2883984 Disease Relevance 1.22 Pain Relevance 0

General Comments

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