INT20687

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Context Info
Confidence 0.35
First Reported 1984
Last Reported 1990
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
blood 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 10 100.00 Very High Very High Very High
Catecholamine 2 95.40 Very High Very High Very High
agonist 2 93.80 High High
Intracerebroventricular 1 66.80 Quite High
medulla 1 65.44 Quite High
Disease Link Frequency Relevance Heat
Hypertension 7 99.88 Very High Very High Very High
Hypotension 7 92.84 High High
Pressure Volume 2 Under Development 1 70.00 Quite High
Sprains And Strains 2 68.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneously hypertensive rats showed greater methylnorepinephrine production, larger up regulation of alpha 1-adrenergic receptors, and greater down regulation of alpha 2-adrenergic receptors than did the normotensive animals; these changes may be physiological markers for the greater antisympathetic action of methyldopa in hypertensive animals.
Positive_regulation (showed) of Regulation (regulation) of alpha 2-adrenergic associated with hypertension
1) Confidence 0.35 Published 1984 Journal Hypertension Section Abstract Doc Link 6094347 Disease Relevance 0.70 Pain Relevance 0.24
The results of the present study indicate that the alpha 2-adrenergic receptor-mediated effects of clonidine on the GH release and blood pressure might be dependent on the endogenous testosterone secretion.
Spec (might) Positive_regulation (dependent) of Regulation (effects) of alpha 2-adrenergic in blood associated with clonidine
2) Confidence 0.24 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.37 Pain Relevance 0.70

General Comments

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