INT206876

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (ANXA1) cilium (ANXA1) protein complex (ANXA1)
lipid metabolic process (ANXA1) cytoplasm (ANXA1) signal transduction (ANXA1)
ANXA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 53 99.36 Very High Very High Very High
Inflammation 62 92.64 High High
cINOD 7 60.00 Quite High
Inflammatory marker 10 52.52 Quite High
cytokine 3 51.72 Quite High
Analgesic 1 25.84 Quite Low
fibrosis 2 22.56 Low Low
tolerance 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 144 98.64 Very High Very High Very High
INFLAMMATION 75 92.64 High High
Apoptosis 18 90.56 High High
Cancer 45 87.80 High High
Rheumatoid Arthritis 47 80.56 Quite High
Overweight 11 74.76 Quite High
Obesity 25 64.60 Quite High
Acute-phase Reaction 4 56.72 Quite High
Disease 15 50.12 Quite High
Diabetes Mellitus 6 44.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While no change in PBMC COX-2 expression was detected, annexin A1 (ANXA1) expression was induced in response to diclofenac, increasing 64 ± 41% (mean ± stdev) in this cell type.
Positive_regulation (induced) of Gene_expression (expression) of ANXA1 associated with diclofenac
1) Confidence 0.39 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.73 Pain Relevance 0.49
signaling, thought to inhibit fibroid growth and survival, at two points in the PPAR pathway: 1) through increased ANXA1 gene expression which can inhibit phospholipase A2 activity and in turn decrease arachidonic acid synthesis, and 2) by decreasing L-PGDS expression which would reduce synthesis of PGJ2, an endogenous ligand for PPAR?.
Positive_regulation (increased) of Gene_expression (expression) of ANXA1 associated with uterine fibroids
2) Confidence 0.23 Published 2007 Journal BMC Womens Health Section Abstract Doc Link PMC1852551 Disease Relevance 0.63 Pain Relevance 0
mediated signaling first by up-regulating ANXA1 gene expression, thereby inhibiting phospholipase A2 activity and reducing arachinoic acid production, a common substrate for prostaglandin synthesis.
Positive_regulation (regulating) of Gene_expression (expression) of ANXA1
3) Confidence 0.23 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.32 Pain Relevance 0.03

General Comments

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