INT206880

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.02
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALDH1A1) small molecule metabolic process (ALDH1A1) oxidoreductase activity (ALDH1A1)
cytoplasm (ALDH1A1)
Anatomy Link Frequency
uterine 2
midbrain 2
ALDH1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 22 100.00 Very High Very High Very High
alcohol 4 78.76 Quite High
Central nervous system 6 75.92 Quite High
fibrosis 4 41.76 Quite Low
Substantia nigra 18 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 92 99.84 Very High Very High Very High
Uterine Fibroids 288 96.68 Very High Very High Very High
Cancer 90 90.08 High High
Death 34 88.56 High High
Apoptosis 54 88.12 High High
Colon Cancer 4 45.72 Quite Low
Cirrhosis 4 41.76 Quite Low
Smooth Muscle Tumor 4 25.00 Low Low
Disease 32 5.00 Very Low Very Low Very Low
Neuroblastoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our integrated analysis of expression data collected by independent studies revealed that expression of two genes, ALDH1A1 and CRABP2 for RA synthesis or mobilization was differentially expressed in human uterine fibroids and regulated by estrogen in the rat uterus.
Gene_expression (expression) of ALDH1A1 in uterine associated with uterine fibroids and rheumatoid arthritis
1) Confidence 0.45 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.45 Pain Relevance 0.04
Reduction of ALDH1A1 expression (Table 3) may not directly result from estrogen regulation but rather be due to feedback inhibition by RA [55].
Gene_expression (expression) of ALDH1A1 associated with rheumatoid arthritis
2) Confidence 0.45 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.30 Pain Relevance 0.03
Previous studies in rodents have suggested that estrogen directly induces uterine RA synthesis by increasing expression of epithelial retinal dehydrogenase (eRolDH) and ALDH1A2 (reviewed in [29]).
Gene_expression (expression) of retinal dehydrogenase in uterine associated with rheumatoid arthritis
3) Confidence 0.39 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.31 Pain Relevance 0.03
Lastly, estrogen affects retinoic acid (RA) synthesis and mobilization by regulating expression of CRABP2 and ALDH1A1.
Gene_expression (expression) of ALDH1A1 associated with rheumatoid arthritis
4) Confidence 0.35 Published 2007 Journal BMC Womens Health Section Abstract Doc Link PMC1852551 Disease Relevance 0.73 Pain Relevance 0
Cultures expressed the midbrain dopaminergic markers, PITX3, En1, TH, Msx1, and Aldh1 (Figures 2D–2H), supporting the notion that hESC-derived cells were committed to a midbrain dopaminergic phenotype.
Gene_expression (expressed) of Aldh1 in midbrain associated with midbrain
5) Confidence 0.30 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525922 Disease Relevance 0.18 Pain Relevance 0.13
The cultured cells also expressed other midbrain dopaminergic markers (PITX3, En1, Msx1, and Aldh1), suggesting that some had differentiated into midbrain dopaminergic neurons.
Gene_expression (expressed) of Aldh1 in midbrain associated with midbrain
6) Confidence 0.30 Published 2007 Journal Frontiers in Neuroanatomy Section Abstract Doc Link PMC2525922 Disease Relevance 0.06 Pain Relevance 0.21

General Comments

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