INT206888

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) endoplasmic reticulum (Calcrl)
plasma membrane (Calcrl) lysosome (Calcrl) signal transducer activity (Calcrl)
Anatomy Link Frequency
uterine 2
Calcrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 1 92.32 High High
Calcitonin gene-related peptide 17 63.20 Quite High
antagonist 39 54.64 Quite High
cytokine 23 25.44 Quite Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
agonist 23 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 72 98.56 Very High Very High Very High
Cancer 44 89.44 High High
Apoptosis 10 81.88 Quite High
Stress 48 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 31 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During pregnancy, the expression of RAMP-3 is strongly increased whereas RAMP-2 and CLR expression are depressed.
Negative_regulation (depressed) of Gene_expression (expression) of CLR
1) Confidence 0.26 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09
Using a rat uterine fibroid-derived cell line (ELT3), Thota and Yallampalli [34] demonstrated that expression of CALCRL and RAMP1 increased with progesterone and decreased with estrogen, consistent with what Helvering et al found in the array work (Table 3).
Negative_regulation (decreased) of Gene_expression (expression) of CALCRL in uterine associated with uterine fibroids
2) Confidence 0.20 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.83 Pain Relevance 0.05

General Comments

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