INT20690

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Context Info
Confidence 0.10
First Reported 1990
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnnm2)
Anatomy Link Frequency
brain 1
Cnnm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 3 100.00 Very High Very High Very High
opiate 1 99.92 Very High Very High Very High
antinociception 44 99.48 Very High Very High Very High
Antinociceptive 31 90.96 High High
Spinal cord 44 90.12 High High
agonist 32 87.92 High High
intrathecal 35 82.72 Quite High
Serotonin 1 70.32 Quite High
epidural 2 61.52 Quite High
Potency 1 57.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 93.44 High High
Paralysis 9 81.60 Quite High
Nociception 13 50.00 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The affinity for several other rat brain receptors such as 5-HT1A, alpha 2-adrenergic, dopamine D1, muscarinic M1 and M2, opiate sigma and beta 2-adrenergic was low.
Regulation (affinity) of M2 in brain associated with dopamine and opiate
1) Confidence 0.10 Published 1990 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2154737 Disease Relevance 0 Pain Relevance 0.30
It has been suggested that cholinergic antinociception may be due to M1 and M2 receptor subtypes so perhaps M2 is responsible for thermal antinociception [25].
Regulation (responsible) of M2 associated with antinociception
2) Confidence 0.01 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.18 Pain Relevance 0.98

General Comments

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