INT206913

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.55
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Anatomy Link Frequency
PDCs 1
mammary gland 1
gonadal 1
B cells 1
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 27 100.00 Very High Very High Very High
Inflammation 45 87.52 High High
Arthritis 82 77.76 Quite High
addiction 2 77.52 Quite High
Inflammatory response 4 50.00 Quite Low
rheumatoid arthritis 12 35.28 Quite Low
antagonist 4 16.44 Low Low
agonist 32 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 133 99.96 Very High Very High Very High
Aids-related Complex 81 99.74 Very High Very High Very High
Systemic Lupus Erythematosus 95 98.96 Very High Very High Very High
Sprains And Strains 66 97.56 Very High Very High Very High
Body Weight 77 97.52 Very High Very High Very High
INFLAMMATION 47 87.52 High High
Feminization 4 86.20 High High
Disease 11 78.04 Quite High
Experimental Arthritis 49 77.76 Quite High
Arthritis 41 73.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
secretion, we propose that E2 activates B cells viability through promoting PDCs to secrete more IFN-?
Localization (secrete) of E2 in B cells
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08
Morphometric parameters of the mammary gland: response to E2
Localization (response) of E2 in mammary gland
2) Confidence 0.30 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.44 Pain Relevance 0
E2 is believed to etiology of both human and murine SLE, but there is little knowledge about the immune state of PDCs under the E2 environment.
Localization (etiology) of E2 associated with systemic lupus erythematosus
3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.32 Pain Relevance 0
-estradiol (E2) and CpG respectively or both in vitro, then cell viability, costimulatory molecule expression, cytokine secretion of PDCs, as well as stimulatory capacity of PDCs to B cells were analyzed.
Localization (secretion) of E2 in PDCs associated with cytokine
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793013 Disease Relevance 0.19 Pain Relevance 0.05
Ovariectomy in rodents increases WAT mass, and E2 replacement decreases WAT mass [94].
Localization (decreases) of E2 replacement associated with obesity
5) Confidence 0.27 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.49 Pain Relevance 0
Finally, we observed that the kisspeptin immunoreactive staining pattern in the ARC is dependent upon gonadal status and is reversible, as kisspeptin staining in the ARC of hpg mice treated with E2 is converted to a WT pattern.
Localization (treated) of E2 in gonadal associated with aids-related complex
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.35 Pain Relevance 0.04
However, defeminization can occur by an increased level of estradiol [6,33,34], and perhaps masculinization by affecting cyclooxygenase-2 (COX-2) regulation to increase prostaglandin E2 (PGE2) [35].
Localization (increase) of E2
7) Confidence 0.17 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.09 Pain Relevance 0
Indeed, E2 was found to suppress NF?
Localization (found) of E2
8) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.68 Pain Relevance 0.25

General Comments

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