INT206938

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.99
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp9) peptidase activity (Casp9) mitochondrion (Casp9)
nucleus (Casp9) cytoplasm (Casp9)
Anatomy Link Frequency
liver 1
Casp9 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 90.52 High High
Inflammation 49 57.28 Quite High
Paracetamol 1 50.80 Quite High
Inflammatory response 2 42.08 Quite Low
Bile 5 32.08 Quite Low
ischemia 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 143 100.00 Very High Very High Very High
Death 33 100.00 Very High Very High Very High
Stress 141 98.08 Very High Very High Very High
Necrosis 12 93.80 High High
Cancer 45 93.44 High High
Increased Venous Pressure Under Development 1 87.52 High High
Injury 44 72.00 Quite High
Hepatotoxicity 25 71.20 Quite High
Pancreatic Cancer 61 70.96 Quite High
Shock 7 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results also suggest that the ER stress elicited by methapyrilene leads to hepatocellular apoptosis/cell death, as evidenced by the up-regulation of genes involved in apoptosis/cell death, including caspase 9, caspase 11, caspase 12, and BCL-associated X protein.
Regulation (regulation) of caspase 9 associated with stress, apoptosis and death
1) Confidence 0.44 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 1.42 Pain Relevance 0.05
These studies provide support that apoptosis could occur in the absence of any significant alterations in caspase 9 activity or cleaved caspase 9 protein content with CR.
Regulation (alterations) of caspase 9 associated with apoptosis
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.45 Pain Relevance 0.03
Furthermore, short-term CR (2 mo; 60% of AL) increased apoptosis in the liver of male rats in the absence of significant changes in caspase 9 or cleaved caspase 9 protein content [95].
Regulation (changes) of caspase 9 in liver associated with apoptosis
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.42 Pain Relevance 0
can induce apoptosis via recruiting TNFR-associated death domain protein (TRADD), FADD, and Caspase-8, and then modulate Caspase-9 and Caspase-3.
Regulation (modulate) of Caspase-9 associated with apoptosis and death
4) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.09 Pain Relevance 0.05
Activation of Akt-1 by phosphrylation at serine 473 was shown to lead to survival pathway [30] via regulation of proapoptotic proteins such as Bad, caspase 9 and p53 [28].
Regulation (regulation) of caspase 9
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.62 Pain Relevance 0

General Comments

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