INT206943

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspa5, Atf4) unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Hspa5 (Rattus norvegicus)
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 5 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Hepatotoxicity 25 97.60 Very High Very High Very High
Stress 26 96.02 Very High Very High Very High
Apoptosis 6 51.24 Quite High
Death 4 50.84 Quite High
Toxicity 28 38.52 Quite Low
Repression 5 5.00 Very Low Very Low Very Low
Biliary Cancer 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twenty-nine genes involved in the ER stress response and/or unfolded protein binding were identified in the hepatotoxicity patterns (nos. 1, 4, 6), including genes such as eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1), heat shock 70 kDa protein 5 (Hspa5), and activating transcription factor 4 (Atf4).
heat shock 70 kDa protein 5 Positive_regulation (activating) of Atf4 associated with stress, shock and hepatotoxicity
1) Confidence 0.47 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.62 Pain Relevance 0

General Comments

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