INT206943

Context Info Confidence 0.47 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0

nucleus (Hspa5, Atf4) unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)

Hspa5 (Rattus norvegicus) Atf4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 5 5.00 Paracetamol 1 5.00

Disease Link Frequency Relevance Heat Shock 3 100.00 Hepatotoxicity 25 97.60 Stress 26 96.02 Apoptosis 6 51.24 Death 4 50.84 Toxicity 28 38.52 Repression 5 5.00 Biliary Cancer 2 5.00 Necrosis 2 5.00 Injury 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Twenty-nine genes involved in the ER stress response and/or unfolded protein binding were identified in the hepatotoxicity patterns (nos. 1, 4, 6), including genes such as eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1), heat shock 70 kDa protein 5 (Hspa5), and activating transcription factor 4 (Atf4).

heat shock 70 kDa protein 5 Positive_regulation (activating) of Atf4 associated with stress, shock and hepatotoxicity

1) Confidence 0.47 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.62 Pain Relevance 0

General Comments

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