INT206944

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.42
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Casp4)
Casp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 1 50.80 Quite High
Bile 5 32.08 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 6 100.00 Very High Very High Very High
Death 4 100.00 Very High Very High Very High
Stress 26 98.08 Very High Very High Very High
Hepatotoxicity 25 72.16 Quite High
Shock 3 70.68 Quite High
Hepatitis 1 55.20 Quite High
Biliary Cancer 2 34.44 Quite Low
Toxicity 28 32.64 Quite Low
Injury 2 25.32 Quite Low
Repression 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results also suggest that the ER stress elicited by methapyrilene leads to hepatocellular apoptosis/cell death, as evidenced by the up-regulation of genes involved in apoptosis/cell death, including caspase 9, caspase 11, caspase 12, and BCL-associated X protein.
Regulation (regulation) of caspase 11 associated with stress, apoptosis and death
1) Confidence 0.44 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 1.42 Pain Relevance 0.05

General Comments

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