INT206946

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.20
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Rxra) nucleus (Rxra) enzyme binding (Rxra)
DNA binding (Rxra) transcription factor binding (Rxra)
Anatomy Link Frequency
hippocampus 1
Rxra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 3 77.96 Quite High
Hippocampus 5 74.12 Quite High
Dopamine 35 66.36 Quite High
Bile 11 57.44 Quite High
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 96.48 Very High Very High Very High
Repression 14 96.40 Very High Very High Very High
Thyroid Disease 6 93.12 High High
Autism 8 90.64 High High
Psychosis 7 90.32 High High
Hepatotoxicity 52 65.36 Quite High
Toxicity 67 56.64 Quite High
Apoptosis 24 53.00 Quite High
Death 16 52.60 Quite High
Congenital Anomalies 44 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NM_022941) and retinoid X receptor alpha (RXRa; GenBank accession no.
Neg (no) Gene_expression (accession) of retinoid X receptor alpha
1) Confidence 0.60 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.52 Pain Relevance 0.03
NM_022941) and retinoid X receptor alpha (RXRa; GenBank accession no.
Neg (no) Gene_expression (accession) of RXRa
2) Confidence 0.60 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.51 Pain Relevance 0.03
A number of xenobiotic metabolism related receptors of interest were present on the array but were either not differentially expressed (pregnane X receptor, Nr1i2; constitutive androstane receptor, Nr1i3; aryl hydrocarbon receptor, Ahr; peroxisome proliferator-activated receptor alpha and gamma, Ppara/Pparg; retinoid x receptor alpha and beta, Rxra/Rxrb) or minimally passed threshold criteria for differential expression (retinoid X receptor, Rxrg).
Neg (not) Gene_expression (expressed) of retinoid x receptor alpha
3) Confidence 0.23 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
BPA increases RARalpha and retinoid X receptor alpha mRNA expression in the cerebrum and cerebellum of male and female mouse embryos.76 In Xenopus (tadpole) tail culture, BPA upregulates thyroid hormone receptor alpha and beta and downregulates RXRgamma.236 When rats are fed BPA during pregnancy and lactation, total thyroid hormone T4 increases in the dentate gyrus of offspring without effect on thyroid-stimulating hormone.237 These changes are accompanied by upregulation of the thyroid hormone-response gene that encodes RC3/neurogranin.237 Another study of perinatal BPA exposure found RC3/neurogranin expression was unchanged by BPA administration, but steroid receptor coactivator-1 was upregulated in the hippocampus of male pups.238 In that study, exposed dams developed temporary hypothyroidism, but male pups developed transient hyperthyroidism followed by hypothyroidism.
Gene_expression (expression) of retinoid X receptor alpha mRNA in hippocampus associated with thyroid disease and hippocampus
4) Confidence 0.14 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.17 Pain Relevance 0.11

General Comments

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