INT206947

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.40
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ppp1r15a) response to stress (Ppp1r15a)
Anatomy Link Frequency
liver 2
Ppp1r15a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 2 72.12 Quite High
Bile 10 53.40 Quite High
Disease Link Frequency Relevance Heat
Stress 52 99.98 Very High Very High Very High
Shock 6 92.00 High High
Apoptosis 12 80.08 Quite High
Hepatitis 2 76.52 Quite High
Hepatotoxicity 50 70.96 Quite High
Death 8 63.28 Quite High
Biliary Cancer 4 55.76 Quite High
Toxicity 56 53.96 Quite High
Injury 4 46.64 Quite Low
Repression 10 25.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, ER stress-inducible genes, such as Atf4, Gadd34/Myd116, and Ddit3/CHOP, are up-regulated in the liver after high-dose methapyrilene administration.
Positive_regulation (inducible) of Gadd34 in liver associated with stress
1) Confidence 0.20 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 1.20 Pain Relevance 0.10
Furthermore, ER stress-inducible genes, such as Atf4, Gadd34/Myd116, and Ddit3/CHOP, are up-regulated in the liver after high-dose methapyrilene administration.
Positive_regulation (inducible) of Myd116 in liver associated with stress
2) Confidence 0.20 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 1.20 Pain Relevance 0.10

General Comments

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