INT206948

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3)
DNA binding (Nr1i3) cytoplasm (Nr1i3)
Anatomy Link Frequency
CAR 2
Nr1i3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 5 49.44 Quite Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 5 88.40 High High
Apoptosis 6 58.24 Quite High
Death 4 57.84 Quite High
Hepatotoxicity 25 57.36 Quite High
Toxicity 28 48.64 Quite Low
Injury 2 29.52 Quite Low
Pathologic Processes 1 29.04 Quite Low
Biliary Cancer 2 12.32 Low Low
Stress 26 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coupled with the down-regulation of PXR, methapyrilene also induced a liver-dependent down-regulation of the constitutive androstane receptor (CAR/Nr1i3; GenBank accession no.
Positive_regulation (induced) of Negative_regulation (regulation) of androstane receptor in CAR
1) Confidence 0.03 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.51 Pain Relevance 0

General Comments

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