INT206948

Context Info Confidence 0.03 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3) DNA binding (Nr1i3) cytoplasm (Nr1i3)

Anatomy Link Frequency CAR 2 Nr1i3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 5 49.44 Paracetamol 1 5.00

Disease Link Frequency Relevance Heat Repression 5 88.40 Apoptosis 6 58.24 Death 4 57.84 Hepatotoxicity 25 57.36 Toxicity 28 48.64 Injury 2 29.52 Pathologic Processes 1 29.04 Biliary Cancer 2 12.32 Stress 26 5.00 Shock 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Coupled with the down-regulation of PXR, methapyrilene also induced a liver-dependent down-regulation of the constitutive androstane receptor (CAR/Nr1i3; GenBank accession no.

Positive_regulation (induced) of Negative_regulation (regulation) of androstane receptor in CAR

1) Confidence 0.03 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.51 Pain Relevance 0

General Comments

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