INT206952

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2)
Anatomy Link Frequency
bile 1
Nr1i2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 5 98.92 Very High Very High Very High
Kinase C 1 82.00 Quite High
Paracetamol 1 27.52 Quite Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 28 99.18 Very High Very High Very High
Toxicity 32 98.52 Very High Very High Very High
Repression 5 91.24 High High
Injury 2 77.92 Quite High
Adenovirus Infection 7 76.56 Quite High
Infection 10 67.24 Quite High
Biliary Cancer 2 60.72 Quite High
Stress 26 43.28 Quite Low
Apoptosis 6 31.48 Quite Low
Death 4 31.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down-regulation of PXR may contribute to the hepatotoxicity of methapyrilene, as the ligand-induced activation of PXR serves to protect against bile acid toxicity resulting from several hepatotoxicants (Staudinger et al. 2001), whereas the resistance to bile acid toxicity is lost in mice lacking PXR (Xie et al. 2000).
Positive_regulation (activation) of PXR in bile associated with toxicity, bile and hepatotoxicity
1) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.67 Pain Relevance 0.17
Ding and Staudinger described an increase in PXR activity in the presence of compounds that induced protein kinase A in vitro [38].
Positive_regulation (increase) of PXR
2) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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