INT206969

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.32
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
Anatomy Link Frequency
skeletal muscle cells 1
AsPC-1 1
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 95.44 Very High Very High Very High
agonist 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 271 100.00 Very High Very High Very High
Pancreatic Cancer 186 98.72 Very High Very High Very High
Malignant Neoplastic Disease 17 97.56 Very High Very High Very High
Cancer 174 96.48 Very High Very High Very High
Lung Cancer 7 93.20 High High
Colon Cancer 21 80.84 Quite High
Stress 10 72.80 Quite High
Death 31 71.28 Quite High
Injury 23 69.88 Quite High
Repression 2 69.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated that in AsPC-1 cells, LN-induced FAK phosphorylation mediated the intrinsic chemoresistance to Gem, and this effect might be related with the regulation of survivin and pBad (pS136) level

Effects of PF-228 on Gem-induced apoptosis in pancreatic cancer cells

Regulation (regulation) of pBad in AsPC-1 associated with pancreatic cancer and apoptosis
1) Confidence 0.15 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.47 Pain Relevance 0
The apoptotic regulatory proteins, which were analyzed, include the following: Bad, Bak, Mcl-1, Bcl-2, Bcl-x, Mdm-2, and Bax.
Regulation (following) of Bad associated with apoptosis
2) Confidence 0.10 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.46 Pain Relevance 0
No change was found on Bad.
Regulation (change) of Bad
3) Confidence 0.10 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.47 Pain Relevance 0
No change was found on Bad
Regulation (change) of Bad
4) Confidence 0.10 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.76 Pain Relevance 0
In our study, corresponding with the alteration of Akt, pBad (pS136) was regulated by constitutive and induced FAK phosphorylation in pancreatic cancer cells.
Regulation (regulated) of pBad associated with pancreatic cancer
5) Confidence 0.07 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.89 Pain Relevance 0
was involved in inducing apoptosis with modulation of Bcl-2 and Bad proteins.
Regulation (modulation) of Bad associated with apoptosis
6) Confidence 0.06 Published 2007 Journal PPAR Research Section Abstract Doc Link PMC1852897 Disease Relevance 0.88 Pain Relevance 0.05
Pro-apoptosis protein Bad is modulated by phosphorylation at two sites, Ser112 (ERK-dependent) and Ser136 (Akt-dependent).
Regulation (modulated) of Bad associated with apoptosis
7) Confidence 0.06 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.81 Pain Relevance 0
It is known that activated PI3K/Akt promotes cell survival via the direct regulation of antiapoptotic Bcl-2 and apoptotic proteins including BAD, BCL-XL, and caspase-9 [43, 44], and that PI3K/Akt pathway is also involved in protecting skeletal muscle cells against oxidative damage [45].
Regulation (regulation) of BAD in skeletal muscle cells associated with apoptosis
8) Confidence 0.04 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.59 Pain Relevance 0

General Comments

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