INT206970

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.30
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 68.04 Quite High
COX-2 inhibitor 8 67.72 Quite High
antagonist 17 55.08 Quite High
ischemia 22 53.04 Quite High
cINOD 4 25.36 Quite Low
Angina 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 180 98.92 Very High Very High Very High
Cancer 110 98.64 Very High Very High Very High
Colon Cancer 70 97.92 Very High Very High Very High
Glioblastoma 1 90.16 High High
Carcinoma 18 87.12 High High
Hepatocellular Cancer 2 86.80 High High
Polyps 1 78.08 Quite High
Hyperlipidemia 1 77.68 Quite High
Malignant Neoplastic Disease 6 75.60 Quite High
Adenoma 8 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiapoptotic protein Bcl-2 and inactive phosphorylated form of Bad (Figures 1 and 2) were increased in all cancer specimens, with no differences among Duke's stages, whereas the proapototic proteins Bad and Bak were decreased (Figure 2).


Negative_regulation (decreased) of Bad associated with cancer
1) Confidence 0.22 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.57 Pain Relevance 0
decreased; (4) the antiapoptotic proteins Bcl-2 and pBad increased, whereas the proapototic proteins Bad and Bak decreased.
Negative_regulation (decreased) of Bad
2) Confidence 0.22 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.98 Pain Relevance 0.09
induction, Bcl-2 decrease, and Bad
Negative_regulation (decrease) of Bad
3) Confidence 0.19 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.27 Pain Relevance 0
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Negative_regulation (inhibition) of Bad associated with apoptosis
4) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.48 Pain Relevance 0.09

General Comments

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