INT206972

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
hepatocyte 2
epithelial cells 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 56 72.72 Quite High
antagonist 16 30.12 Quite Low
cINOD 8 24.88 Low Low
Inflammation 21 17.96 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 87 97.68 Very High Very High Very High
Colon Cancer 51 96.64 Very High Very High Very High
Necrosis 6 92.60 High High
Stress 4 91.52 High High
Cancer 98 89.76 High High
Hepatocellular Cancer 12 85.92 High High
Lung Cancer 7 84.88 Quite High
Gastrointestinal Neoplasms 8 68.08 Quite High
Adenocarcinoma 6 65.36 Quite High
Stomach Cancer 2 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No

univocal changes were observed for PPAR?

Neg (No) Regulation (changes) of Localization (observed) of PPAR
1) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.92 Pain Relevance 0
important, whereas the modification of PPAR?
Regulation (important) of Localization (modification) of PPAR
2) Confidence 0.39 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.08 Pain Relevance 0.04
regulates the differentiation of human gastrointestinal epithelial cells are not yet clear, but may involve a collaboration of PPAR?
Regulation (regulates) of Localization (collaboration) of PPAR in epithelial cells
3) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.40 Pain Relevance 0
Several PPAR target genes, such as CYP4A1, CPT1, or CD36, were induced in the two hepatocyte cultures treated by 40??
Regulation (target) of Localization (Several) of PPAR in hepatocyte
4) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.09 Pain Relevance 0

General Comments

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