INT206982

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TDO2) small molecule metabolic process (TDO2) oxidoreductase activity (TDO2)
cellular nitrogen compound metabolic process (TDO2)
Anatomy Link Frequency
hair 1
TDO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sclerosis 1 97.56 Very High Very High Very High
Syndrome 11 93.08 High High
Constipation 120 90.72 High High
Amelogenesis Imperfecta 81 88.56 High High
Colon Cancer 12 80.08 Quite High
Diarrhoea 16 58.04 Quite High
Congenital Anomalies 5 48.72 Quite Low
Open Bite 4 47.80 Quite Low
Rod Or Cone Dystrophy 4 43.12 Quite Low
Inborn Genetic Diseases 2 38.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of the present study showed a significant decrease in the activities of tryptophanase and urease, which are harmful enzymes comprising the intestinal microflora, by 43% and 30% in subjects after LAB treatment, respectively (p values are 0.047 and 0.005).
Negative_regulation (decrease) of tryptophanase
1) Confidence 0.19 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0.17 Pain Relevance 0
After LAB treatment, tryptophanase and urease activities were decreased by 43% and 30%, respectively.
Negative_regulation (decreased) of tryptophanase
2) Confidence 0.14 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0 Pain Relevance 0
In addition, tryptophanase and urease among harmful enzyme activities of intestinal microflora were significantly decreased (p < 0.05) after LAB treatment.


Negative_regulation (decreased) of tryptophanase
3) Confidence 0.14 Published 2010 Journal Nutr J Section Abstract Doc Link PMC2835640 Disease Relevance 0.40 Pain Relevance 0
Furthermore, there was a statistically significant decrease in both tryptophanase (p = 0.047) and urease (p = 0.005) activities.
Negative_regulation (decrease) of tryptophanase
4) Confidence 0.14 Published 2010 Journal Nutr J Section Body Doc Link PMC2835640 Disease Relevance 0 Pain Relevance 0
While the hair changes might represent a common ectodermal defect in TDO, the bony changes are more difficult to explain via a common pathway, as this assumes a mesodermal defect.
Negative_regulation (defect) of TDO in hair
5) Confidence 0.10 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1853073 Disease Relevance 0.94 Pain Relevance 0

General Comments

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