INT207005

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.85
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
dorsal horn 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 22 100.00 Very High Very High Very High
bDMF 18 100.00 Very High Very High Very High
spinal dorsal horn 2 98.68 Very High Very High Very High
depression 86 96.96 Very High Very High Very High
intrathecal 10 96.08 Very High Very High Very High
Pyramidal cell 20 94.28 High High
long-term potentiation 22 89.60 High High
qutenza 5 83.20 Quite High
IPN 4 80.88 Quite High
Dorsal horn neuron 6 80.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 41 100.00 Very High Very High Very High
Aids-related Complex 131 99.80 Very High Very High Very High
Neurological Disease 8 98.60 Very High Very High Very High
Suicidal Behaviour 123 97.28 Very High Very High Very High
Depression 108 96.96 Very High Very High Very High
Targeted Disruption 63 92.64 High High
Disease Susceptibility 1 91.76 High High
Stress 25 91.36 High High
Mental Disorders 6 90.92 High High
Anxiety Disorder 50 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, what role does dendritic localization of BDNF/TrkB play in altered plasticity in these disorders?
Regulation (play) of Localization (localization) of BDNF
1) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.74 Pain Relevance 0.14
To investigate the effect of these isoforms on BDNF releasing activity, we exogenously expressed the three long isoforms (CAPS2a-c) together with BDNF in PC12 cells.
Spec (investigate) Regulation (effect) of Localization (releasing) of BDNF
2) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
Region specific Cre gene expression and BDNF deletion were confirmed with in situ hybridization, x-gal staining for ?
Regulation (confirmed) of Localization (deletion) of BDNF
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.26 Pain Relevance 0.04
Taken together, our findings are in line with the idea that release of glutamate and/or BDNF from activated nociceptive fibers are at least partly responsible for Arc/Arg3.1 induction in the spinal dorsal horn.
Regulation (responsible) of Localization (release) of BDNF in dorsal horn associated with nociception, glutamate, aids-related complex, spinal dorsal horn and bdmf
4) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.45 Pain Relevance 0.88
These results demonstrate that the splicing variations correlate with their expression patterns and intracellular distribution, and affect BDNF release; however, whether or not the short forms possess activities other than BDNF release, for example as natural dominant-negative isoforms, remains to be determined.



Regulation (affect) of Localization (release) of BDNF
5) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
In CNS, physiological activities regulate local BDNF synthesis and secretion, providing neurotrophic support necessary for the BDNF-responsive tissues in a timely, dynamic fashion.
Regulation (regulate) of Localization (secretion) of BDNF
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.39 Pain Relevance 0.17
However, to conclusively test this hypothesis the direct effect of BDNF on the IAHP and the signal transduction steps leading from BDNF release to the modulation of SK channel activity need to be scrutinized and studied in detail.
Regulation (modulation) of Localization (release) of BDNF
7) Confidence 0.13 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.22

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