INT207035

Context Info Confidence 0.63 First Reported 2007 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 15 Disease Relevance 18.40 Pain Relevance 1.72

peptidase activity (CFB) extracellular region (CFB) plasma membrane (CFB)

Anatomy Link Frequency adipose tissue 6 endothelial cells 1 fat 1 monocytes 1 fibroblasts 1 CFB (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 187 98.56 rheumatoid arthritis 100 95.92 Inflammation 100 87.16 Multiple sclerosis 96 84.56 cytokine 23 46.84 Central nervous system 2 36.72 spinal inflammation 51 7.60 Crohn's disease 26 5.00 alcohol 22 5.00 Arthritis 14 5.00

Disease Link Frequency Relevance Heat Obesity 693 99.98 Insulin Resistance 253 99.50 Impaired Glucose Tolerance 209 98.56 Shock 2 98.04 Disorder Of Lipid Metabolism 99 97.48 Metabolic Disorder 55 96.40 Thyroid Disease 68 96.24 Rheumatoid Arthritis 114 95.92 Disease 408 90.88 Weight Loss 187 89.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Those include polymorphisms in complement factor B (CFB), nuclear envelope membrane protein (NRM), heat shock protein (HSPA1B) as well as others.

Gene_expression (polymorphisms) of CFB associated with shock

1) Confidence 0.63 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 2.24 Pain Relevance 0.56

Inversely, CFB gene expression was increased in omental adipose tissue (0.12 ± 0.08 vs. 0.013 ± 0.007 relative units, P < 0.0001).

Gene_expression (expression) of CFB in adipose tissue associated with obesity

2) Confidence 0.60 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.98 Pain Relevance 0

Those include polymorphisms in complement factor B (CFB), nuclear envelope membrane protein (NRM), heat shock protein (HSPA1B) as well as others.

Gene_expression (polymorphisms) of complement factor B associated with shock

3) Confidence 0.55 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 2.24 Pain Relevance 0.56

In contrast, CFB gene expression was significantly increased in omental fat but also in association with fasting glucose and triglycerides.

Gene_expression (expression) of CFB in fat

4) Confidence 0.54 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.28 Pain Relevance 0.08

The increased expression of CFH and CFB genes in adipose tissue was observed in the SVF cells (composed by monocytes, fibroblasts, and endothelial cells).

Gene_expression (expression) of CFB in fibroblasts associated with obesity

5) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.38 Pain Relevance 0.08

Our objective was to study the associations between circulating and adipose tissue gene expressions of CFH and complement factor B (fB; CFB) with obesity and insulin resistance.

Gene_expression (expressions) of complement factor B in adipose tissue associated with obesity and insulin resistance

6) Confidence 0.54 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.00 Pain Relevance 0.03

CFB gene expression in omental adipose tissue was positively associated with BMI, fasting glucose, and log fasting triglycerides and negatively with HDL cholesterol; CFH gene expression in omental adipose tissue was associated with insulin resistance (Table 3).

Gene_expression (expression) of CFB in adipose tissue associated with obesity, insulin resistance and disorder of lipid metabolism

7) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.00 Pain Relevance 0

CFH and CFB gene expressions were evaluated in 76 adipose tissue samples, in isolated adipocytes, and in stromovascular cells (SVC) (n = 13).

Gene_expression (expressions) of CFB in adipocytes associated with obesity

8) Confidence 0.54 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.15 Pain Relevance 0.04

Adipose tissue CFB gene expression tended to be higher in subjects with insulin resistance (Table 3B), and omental CFB gene expression was significantly associated with fasting glucose and triglycerides (positively) and negatively with HDL cholesterol (Table 3A).

Gene_expression (expression) of CFB in Adipose tissue associated with obesity, insulin resistance and disorder of lipid metabolism

9) Confidence 0.47 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.48 Pain Relevance 0.11

Adipose tissue CFB gene expression tended to be higher in subjects with insulin resistance (Table 3B), and omental CFB gene expression was significantly associated with fasting glucose and triglycerides (positively) and negatively with HDL cholesterol (Table 3A).

Gene_expression (expression) of CFB in Adipose tissue associated with obesity, insulin resistance and disorder of lipid metabolism

10) Confidence 0.47 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.41 Pain Relevance 0.08

Our objective was to study the associations between circulating and adipose tissue gene expressions of CFH and complement factor B (fB; CFB) with obesity and insulin resistance.

Gene_expression (expressions) of CFB in adipose tissue associated with obesity and insulin resistance

11) Confidence 0.47 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 1.01 Pain Relevance 0.03

MHC complement gene haplotypes or complotypes are designated by their BF, C2, C4A, and C4B alleles, in that arbitrary order [7].

Gene_expression (alleles) of BF

12) Confidence 0.27 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

The increased expression of CFH and CFB genes in adipose tissue was observed in the SVF cells (composed by monocytes, fibroblasts, and endothelial cells).

Gene_expression (expression) of CFB in monocytes associated with obesity

13) Confidence 0.18 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.38 Pain Relevance 0.08

The increased expression of CFH and CFB genes in adipose tissue was observed in the SVF cells (composed by monocytes, fibroblasts, and endothelial cells).

Gene_expression (expression) of CFB in endothelial cells associated with obesity

14) Confidence 0.18 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.38 Pain Relevance 0.08

All molecular data on DNA and RNA were produced and analysed by CFB and HdP.

Spec (analysed) Gene_expression (produced) of CFB

15) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2682795 Disease Relevance 0.45 Pain Relevance 0

General Comments

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