INT20705

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.34
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn4a)
Anatomy Link Frequency
cardiac muscle 2
muscle 2
foot 2
brain 1
skeletal muscle 1
Scn4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 14 100.00 Very High Very High Very High
opioid receptor 12 100.00 Very High Very High Very High
Morphine 16 99.84 Very High Very High Very High
nMDA receptor 6 99.36 Very High Very High Very High
tetrodotoxin 18 99.32 Very High Very High Very High
Kinase C 2 99.16 Very High Very High Very High
Thermal hyperalgesia 8 97.88 Very High Very High Very High
Hyperalgesia 2 97.60 Very High Very High Very High
anesthesia 7 97.32 Very High Very High Very High
Inflammation 46 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 99.48 Very High Very High Very High
Herpes Simplex Virus 238 99.26 Very High Very High Very High
Hyperalgesia 14 97.88 Very High Very High Very High
INFLAMMATION 48 97.20 Very High Very High Very High
Sarcoma 79 94.68 High High
Infection 104 91.84 High High
Death 5 76.36 Quite High
Nociception 2 75.00 Quite High
Stress 3 63.44 Quite High
Vascular Neoplasms 1 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Steady-state mRNA levels for SkM1 and SkM2 are regulated differently during development and following denervation: the SkM2 mRNA level is highest in early development, when TTX-insensitive channels predominate, but declines rapidly with age as SkM1 mRNA increases; SkM2 mRNA is not detectable in normally innervated adult skeletal muscle but increases greater than 100-fold after denervation; rat cardiac muscle has abundant SkM2 mRNA but no detectable SkM1 message.
Neg (not) Positive_regulation (increases) of SkM1 in cardiac muscle associated with tetrodotoxin
1) Confidence 0.68 Published 1990 Journal Neuron Section Abstract Doc Link 2155010 Disease Relevance 0 Pain Relevance 0.58
Steady-state mRNA levels for SkM1 and SkM2 are regulated differently during development and following denervation: the SkM2 mRNA level is highest in early development, when TTX-insensitive channels predominate, but declines rapidly with age as SkM1 mRNA increases; SkM2 mRNA is not detectable in normally innervated adult skeletal muscle but increases greater than 100-fold after denervation; rat cardiac muscle has abundant SkM2 mRNA but no detectable SkM1 message.
Positive_regulation (increases) of SkM1 in cardiac muscle associated with tetrodotoxin
2) Confidence 0.68 Published 1990 Journal Neuron Section Abstract Doc Link 2155010 Disease Relevance 0 Pain Relevance 0.58
Surprisingly, denervation of adult muscle was also followed by a rise in microI mRNA, at a time when TTX-insensitive currents reappear.
Positive_regulation (rise) of microI mRNA in muscle associated with tetrodotoxin
3) Confidence 0.47 Published 1990 Journal Dev. Biol. Section Abstract Doc Link 2175278 Disease Relevance 0 Pain Relevance 0.37
Although there was no evidence for endogenous mu-1 opioid activity, this study indicated that stimulation of mu-1 opioid receptors causes a decrease in body temperature in conscious, unrestrained neonatal rats under or close to thermoneutral conditions.
Positive_regulation (stimulation) of mu-1 in body associated with opioid receptor and opioid
4) Confidence 0.41 Published 2002 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12037126 Disease Relevance 0.10 Pain Relevance 0.49
Transcripts for microI were present at low levels in neonatal skeletal muscle and increased to maximum levels in adult tissue, paralleling the expression of tetrodotoxin (TTX)-sensitive sodium currents.
Positive_regulation (increased) of microI in skeletal muscle associated with tetrodotoxin
5) Confidence 0.41 Published 1990 Journal Dev. Biol. Section Abstract Doc Link 2175278 Disease Relevance 0 Pain Relevance 0.36
Telomerase-immortalized human umbilical vein endothelial cells supporting KSHV stable latency (TIVE-LTC) expressed elevated levels of functional COX-2 and microsomal PGE2 synthase (m-PGES), and secreted the predominant eicosanoid inflammatory metabolite PGE2.
Positive_regulation (elevated) of micro in endothelial cells associated with inflammation and herpes simplex virus
6) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.67 Pain Relevance 0.36
HR also increased during microG in conscious animals (microG: 349 +/- 12 beats/min vs. 1 G: 324+9 beats/min; P < 0.01), although no change was observed under anesthesia.
Positive_regulation (increased) of microG associated with anesthesia
7) Confidence 0.19 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 12391062 Disease Relevance 0 Pain Relevance 0.28
Thus, the increase in AD during microG was accounted for by the increase in TP.
Positive_regulation (increase) of microG
8) Confidence 0.18 Published 2003 Journal Jpn. J. Physiol. Section Abstract Doc Link 12877771 Disease Relevance 0 Pain Relevance 0
In conclusion, S5-P-S6 segments of micro1 channels form a toxin-activable ionophore but do not reconstitute the Na+ channel permeation pathway with full fidelity.
Positive_regulation (segments) of micro1
9) Confidence 0.10 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11973330 Disease Relevance 0.15 Pain Relevance 0.21
Our studies showed that (i) MIP-2 injection dose-dependently augmented recruitment of PMN and opioid-containing leukocytes (5-fold increase in cells/paw, P < 0.05), (ii) PPT was not different between groups at baseline and after CWS or CRF (maximum MPE: 20+/-2.3-29+/-7.2%, P < 0.05), (iii) injection of opioid peptides dose-dependently increased the PPT (P < 0.05, maximum MPE: and 18+/-2.6-21+/-3.6%), (iv) MOR (micro OR, MOP) binding sites in the ipsilateral DRG were unchanged (24+/-2-22+/-1.2 fmol/mg protein, P < 0.05, ANOVA) and (v) the number of MOR and DOR (delta OR, DOP) stained nerve fibers in peripheral tissue were unaltered (both P > 0.05, t-test).
Positive_regulation (recruitment) of micro OR in paw associated with opioid receptor and opioid
10) Confidence 0.06 Published 2004 Journal Pain Section Abstract Doc Link 15109509 Disease Relevance 0.41 Pain Relevance 1.53
To examine acute hemodynamic responses to microgravity (microG) in the head, we measured carotid artery pressure (CAP) and jugular vein pressure (JVP) to calculate cephalic perfusion pressure (CPP = CAP - JVP) and recorded images of microvessels in the iris to evaluate capillary blood flow velocity (CBFV) and capillary diameter (CD) in anesthetized rats during 4.5 s of microG induced by free drop.
Positive_regulation (induced) of microG in blood
11) Confidence 0.04 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14764437 Disease Relevance 0 Pain Relevance 0
In these animals, the change in JVP was similar to that observed during actual microG, but no change in CAP was seen, indicating that the JVP increase during actual microG is caused by disappearance of the gravitational pressure gradient in the head-to-foot axis, whereas the CAP increase is not.
Positive_regulation (increase) of microG in foot
12) Confidence 0.04 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14764437 Disease Relevance 0 Pain Relevance 0
Although the increase in JVP is explained by the disappearance of gravitational pressure gradient in the head-to-foot axis as a result of microG, the larger increase in CAP is not.
Positive_regulation (result) of microG in foot
13) Confidence 0.04 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14764437 Disease Relevance 0 Pain Relevance 0
The release of opioids from nerve terminals located in the MPOA, which in turn binds and activates mainly type mu 1-receptors, might contribute to this inhibitory influence of CRF on LHRH release in the infundibular system.
Positive_regulation (activates) of mu 1 in nerve associated with urological neuroanatomy and opioid
14) Confidence 0.03 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.48 Pain Relevance 0.38
Finally, as in cloned brain NaIIA Na+ channels, batrachotoxin abolished both fast and slow inactivation of mu1 Na+ channels.
Positive_regulation (inactivation) of mu1 in brain
15) Confidence 0.03 Published 1996 Journal Pflugers Arch. Section Abstract Doc Link 8764971 Disease Relevance 0 Pain Relevance 0.09
Slow inactivation of muscle mu1 Na+ channels in permanently transfected mammalian cells.
Positive_regulation (inactivation) of mu1 in muscle
16) Confidence 0.03 Published 1996 Journal Pflugers Arch. Section Title Doc Link 8764971 Disease Relevance 0 Pain Relevance 0.12
We investigated the site of action of morphine and the mechanism of action of microOR activation by morphine to NMDA receptor as it relates to acute thermal hyperalgesia.
Positive_regulation (activation) of microOR associated with thermal hyperalgesia, nmda receptor and morphine
17) Confidence 0.02 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17996026 Disease Relevance 0.66 Pain Relevance 1.10
Protein kinase C appears to be the key element that links microOR activation by morphine administration to mice with the recruitment of the NMDA/glutamatergic system involved in the thermal hyperalgesic response.
Positive_regulation (activation) of microOR associated with hyperalgesia, kinase c and morphine
18) Confidence 0.01 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17996026 Disease Relevance 0.87 Pain Relevance 1.42

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