INT207067

Context Info Confidence 0.69 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.59 Pain Relevance 0.04

cytosol (Akt2) transport (Akt2) mitochondrion (Akt2) plasma membrane (Akt2) nucleus (Akt2) carbohydrate metabolic process (Akt2)

Anatomy Link Frequency finger 1 nucleus 1 Akt2 (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 2 77.72 Inflammation 54 50.00 substance P 14 37.16 Inflammatory response 7 5.00 Inflammatory stimuli 5 5.00 anesthesia 4 5.00 cytokine 2 5.00 ketamine 2 5.00 agonist 2 5.00 GABAergic 2 5.00

Disease Link Frequency Relevance Heat Osteogenic Sarcomas 2 100.00 Stress 2 88.56 Shock 2 86.44 Apoptosis 2 70.40 Death 6 67.92 Cancer 9 64.72 Hematological Disease 2 57.20 Myopia 26 53.36 INFLAMMATION 66 50.00 Disease 5 44.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).

Localization (peptidase) of Akt2 in finger associated with osteogenic sarcomas

1) Confidence 0.69 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0

This is the case of elk1, nfkbia, hspb1, dusp1, and akt2.

Localization (case) of akt2

2) Confidence 0.66 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.26 Pain Relevance 0

Furthermore, it has been shown that Akt2 detaches from the inner surface of the plasma membrane, where it is initially activated, and translocates to the nucleus within 30 min of its activation by growth factors [61].

Localization (translocates) of Akt2 in nucleus

3) Confidence 0.65 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

This test has worked.