INT207067

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akt2) transport (Akt2) mitochondrion (Akt2)
plasma membrane (Akt2) nucleus (Akt2) carbohydrate metabolic process (Akt2)
Anatomy Link Frequency
finger 1
nucleus 1
Akt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 77.72 Quite High
Inflammation 54 50.00 Quite Low
substance P 14 37.16 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
GABAergic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 2 100.00 Very High Very High Very High
Stress 2 88.56 High High
Shock 2 86.44 High High
Apoptosis 2 70.40 Quite High
Death 6 67.92 Quite High
Cancer 9 64.72 Quite High
Hematological Disease 2 57.20 Quite High
Myopia 26 53.36 Quite High
INFLAMMATION 66 50.00 Quite Low
Disease 5 44.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Localization (peptidase) of Akt2 in finger associated with osteogenic sarcomas
1) Confidence 0.69 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
This is the case of elk1, nfkbia, hspb1, dusp1, and akt2.
Localization (case) of akt2
2) Confidence 0.66 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.26 Pain Relevance 0
Furthermore, it has been shown that Akt2 detaches from the inner surface of the plasma membrane, where it is initially activated, and translocates to the nucleus within 30 min of its activation by growth factors [61].
Localization (translocates) of Akt2 in nucleus
3) Confidence 0.65 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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