INT207074

Context Info Confidence 0.18 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.87 Pain Relevance 0.48

plasma membrane (Pawr) nucleus (Pawr) enzyme binding (Pawr) cytoplasm (Pawr)

Anatomy Link Frequency urinary bladder 2 Pawr (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 110 99.00 substance P 20 87.84 agonist 4 62.96 Inflammatory stimuli 15 53.76 Inflammatory response 18 51.12 ketamine 3 5.00 cytokine 2 5.00 Pain 2 5.00 c fibre 2 5.00 interstitial cystitis 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 140 99.00 Nociception 1 77.92 Injury 11 73.04 Pressure And Volume Under Development 4 55.52 Carcinoma 12 43.84 Non-genital Cutaneous Warts 1 23.72 Cystitis 18 5.00 Cancer 12 5.00 Overactive Bladder 10 5.00 Disease 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.

PAR4 Binding (recognized) of in urinary bladder

1) Confidence 0.18 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.44 Pain Relevance 0.23

Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.

PAR4 Binding (recognized) of in urinary bladder

2) Confidence 0.15 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.43 Pain Relevance 0.25

General Comments

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