INT207081

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.99
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Plaur) plasma membrane (Plaur) enzyme binding (Plaur)
kinase activity (Plaur)
Plaur (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 13 79.96 Quite High
cva 17 69.76 Quite High
Inflammation 55 68.72 Quite High
dexamethasone 1 66.80 Quite High
substance P 14 54.20 Quite High
Central nervous system 3 28.48 Quite Low
agonist 2 10.24 Low Low
antagonist 14 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 274 99.76 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 158 98.38 Very High Very High Very High
Thrombophilia 5 98.24 Very High Very High Very High
Glioblastoma 33 97.96 Very High Very High Very High
Glioma 152 97.00 Very High Very High Very High
Anaplastic Astrocytoma 7 94.80 High High
Thromboembolism 1 93.36 High High
Brain Tumor 3 91.60 High High
Colon Cancer 9 89.52 High High
Adhesions 112 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plaur is most closely associated with cancer invasion [65].
Plaur Binding (associated) of associated with cancer
1) Confidence 0.31 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.31 Pain Relevance 0.12
Integrins are essential uPAR signaling co-receptors and the interactions between uPAR/?
uPAR Binding (interactions) of
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.12 Pain Relevance 0
Additionally, uPA-uPAR binding results in the expression of cathepsin B [21], another important protease involved in ECM degradation, and significantly higher levels of cathepsin B has been found in high-grade glioblastomas [22], [23].
uPAR Binding (binding) of associated with glioblastoma
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.89 Pain Relevance 0.12
Despite the controversy surrounding whether uPAR and integrins interact directly, many studies show that uPAR signaling requires integrin co-receptors.
uPAR Spec (whether) Binding (interact) of
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.88 Pain Relevance 0.14
Wei et al. recently reported that urokinase receptor binding to ?
urokinase receptor Binding (binding) of
5) Confidence 0.20 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746574 Disease Relevance 0.41 Pain Relevance 0
Both uPAR and cathepsin B are known to be associated in close proximity to ?
uPAR Binding (associated) of
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.55 Pain Relevance 0
1 integrins in caveolae bind uPAR and are linked to increased secretion of pro-cathepsin B [31].
uPAR Binding (bind) of
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.71 Pain Relevance 0
An additional mechanism of thrombophilia in PNH might be the impairment of the fibrinolytic system, due to the lack of membrane-bound urokinase-type plasminogen activator receptor (uPAR), which is GPI-linked, and to the excess of its soluble form (Ninomiya et al 1997; Sloand et al 2006).
urokinase-type plasminogen activator receptor Binding (bound) of associated with thrombophilia and paroxysmal nocturnal hemoglobinuria
8) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.12 Pain Relevance 0.03

General Comments

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