INT207082

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.45
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pars2) translation (Pars2) ligase activity (Pars2)
cytoplasm (Pars2)
Anatomy Link Frequency
bladder 5
plasma 1
SNc 1
mast cell 1
Pars2 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 2 100.00 Very High Very High Very High
Inflammation 416 99.52 Very High Very High Very High
Spinal cord 32 97.92 Very High Very High Very High
substance P 49 96.18 Very High Very High Very High
agonist 11 94.56 High High
Central nervous system 15 91.28 High High
Inflammatory response 65 86.84 High High
cytokine 11 74.96 Quite High
Inflammatory stimuli 31 73.76 Quite High
Dopamine 4 73.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 519 99.52 Very High Very High Very High
Injury 33 98.36 Very High Very High Very High
Urological Neuroanatomy 26 97.92 Very High Very High Very High
Microphthalmia 161 96.96 Very High Very High Very High
Nociception 2 93.68 High High
Cystitis 68 92.92 High High
Mastocytosis 7 92.40 High High
Disease 65 90.80 High High
Adhesions 11 62.76 Quite High
Interstitial Cystitis 30 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note that activation of PARs on the bladder urothelium leads to activation of one of the members of the MiTF family.
Positive_regulation (activation) of PARs in bladder associated with microphthalmia
1) Confidence 0.14 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.50 Pain Relevance 0.07
Our present findings further emphasize that products of mast cells such as tryptase inducing activation of PARs can lead to increased activity of transcription factors such as TFEB that play a fundamental role in mast cell survival.
Positive_regulation (activation) of PARs in mast cell
2) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.70 Pain Relevance 0.25
However, the information regarding endogenous activators of PARs in the mouse bladder is, unfortunately, scanty.
Positive_regulation (activators) of PARs in bladder
3) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.46 Pain Relevance 0.21
Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation

Background

Positive_regulation (activated) of PARs in bladder associated with inflammation
4) Confidence 0.10 Published 2007 Journal BMC Immunol Section Title Doc Link PMC2000913 Disease Relevance 0.39 Pain Relevance 0.19
Involvement of mast cells and PARs in bladder inflammation
Positive_regulation (Involvement) of PARs in bladder associated with inflammation
5) Confidence 0.08 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.84 Pain Relevance 0.29
Along with serine proteases, it seems that tissue factor and element of the coagulation cascade are also endogenous activators of PARs [61,62].
Positive_regulation (activators) of PARs
6) Confidence 0.08 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.56 Pain Relevance 0.21
The findings that TFEB is downstream of activation of all PARs, makes this transcriptional factor a novel therapeutic target for the treatment of inflammatory disorders of the bladder.


Positive_regulation (activation) of PARs in bladder associated with inflammation
7) Confidence 0.08 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.73 Pain Relevance 0.28
The possible mechanisms by which LPS and SP induce PAR activation include degranulation of mast cells with a concomitant release of tryptase and plasma extravasation leading to accumulation of products of the coagulation cascade that activate PARs.
Positive_regulation (activate) of PARs in plasma associated with substance p
8) Confidence 0.08 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.47 Pain Relevance 0.25
The proteases that activate PARs are often generated and secreted during injury and inflammation, and PARs orchestrate tissue responses to these insults, including hemostasis, inflammation, nociception, and repair mechanisms [34].
Positive_regulation (activate) of PARs associated with nociception, inflammation and injury
9) Confidence 0.08 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.55 Pain Relevance 0.25
In the SN, we observed an increase in intracellular alpha-synuclein (Figure 4B) together with larger alpha-synuclein accumulations in the substantia nigra pars compacta (SNc) (Figure 4c) similarly to that within DMV and IML.
Positive_regulation (accumulations) of pars compacta in SNc associated with substantia nigra and spinal cord
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.26 Pain Relevance 0.22

General Comments

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