INT20709

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 1990
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ap2m1) mitochondrion (Ap2m1) vesicle-mediated transport (Ap2m1)
plasma membrane (Ap2m1)
Ap2m1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.04 Very High Very High Very High
Opioid 3 96.94 Very High Very High Very High
narcan 3 92.76 High High
opioid receptor 5 75.00 Quite High
Immobilon 2 70.16 Quite High
Enkephalin 2 67.68 Quite High
agonist 1 58.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The irreversible mu opioid antagonist, beta-funaltrexamine (10 micrograms, i.c.v.: 37%), but not the irreversible mu 1 antagonist, naloxonazine (10 mg/kg, i.v.) inhibited intake, suggesting mu 2 receptor mediation.
Spec (suggesting) Positive_regulation (suggesting) of Positive_regulation (mediation) of mu 2 associated with antagonist and opioid
1) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 2155039 Disease Relevance 0 Pain Relevance 0.37
The evidence suggests that the formation of heterologous kappa-delta or mu 1-mu 2 receptor complexes is required for stabilization of the high-affinity conformational state of the receptor.
Positive_regulation (required) of Positive_regulation (formation) of mu 2
2) Confidence 0.49 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3005504 Disease Relevance 0 Pain Relevance 0.40

General Comments

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