INT207091

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.95
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pawr) nucleus (Pawr) enzyme binding (Pawr)
cytoplasm (Pawr)
Anatomy Link Frequency
bladder 2
Pawr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 29 100.00 Very High Very High Very High
substance P 26 99.32 Very High Very High Very High
Inflammatory stimuli 25 98.82 Very High Very High Very High
Inflammation 166 96.20 Very High Very High Very High
agonist 6 93.88 High High
Potency 2 77.92 Quite High
c fibre 3 77.40 Quite High
Pain 3 16.60 Low Low
ketamine 4 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 214 99.98 Very High Very High Very High
Pressure And Volume Under Development 7 97.48 Very High Very High Very High
Cystitis 30 84.64 Quite High
Overactive Bladder 17 66.04 Quite High
Carcinoma 24 41.04 Quite Low
Cancer 15 32.92 Quite Low
Apoptosis 2 31.04 Quite Low
Death 2 29.76 Quite Low
Pain 3 16.60 Low Low
Disease 5 16.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional evidence for the participation of PARs in the bladder inflammatory response was the finding that known pro-inflammatory stimuli such as LPS, substance P, and antigen challenge induce an increase in PAR4 RNA within four hours [20].
Positive_regulation (increase) of PAR4 in bladder associated with inflammatory response, substance p and inflammatory stimuli
1) Confidence 0.36 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.66 Pain Relevance 0.39
Additional evidence for the participation of PARs in the bladder inflammatory response was the finding that known pro-inflammatory stimuli such as LPS, substance P, and antigen challenge induce an increase in PAR4 RNA within four hours [32].
Positive_regulation (increase) of PAR4 in bladder associated with inflammatory response, substance p and inflammatory stimuli
2) Confidence 0.30 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.78 Pain Relevance 0.45
Interestingly, the inflammatory responses to PAR4-AP peaked at 10 ?
Positive_regulation (responses) of PAR4 associated with inflammatory response
3) Confidence 0.21 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.51 Pain Relevance 0.25

General Comments

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