INT207097

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.63
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid metabolic process (Pla2g6) cytoplasm (Pla2g6)
Anatomy Link Frequency
urothelial cells 1
edge 1
Pla2g6 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 64 81.84 Quite High
agonist 47 80.68 Quite High
addiction 2 71.84 Quite High
qutenza 12 50.32 Quite High
Inflammation 55 50.00 Quite Low
chemokine 2 15.12 Low Low
antagonist 15 5.00 Very Low Very Low Very Low
substance P 14 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 118 98.56 Very High Very High Very High
Skin Cancer 3 50.64 Quite High
INFLAMMATION 68 50.00 Quite Low
Cancer 33 45.92 Quite Low
Urinary Tract Disease 1 35.56 Quite Low
Disease 12 28.92 Quite Low
Embryonic Lethality 4 26.32 Quite Low
Hematological Disease 2 20.88 Low Low
Death 2 14.88 Low Low
Apoptosis 17 13.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second set of experiments was performed in rats to investigate the effects of iPLA2 inhibition on menthol-induced cold hypersensitivity.
Spec (investigate) Regulation (effects) of iPLA2 associated with hypersensitivity
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.38 Pain Relevance 0.10
Because of the prominent role of the calcium-independent phospholipase A2 (iPLA2) in mediating tryptase-activated PAR in bladder microvascular endothelial cells [30], bladder urothelial cells [31,32], and PAR2-AP in bladder contractions [33], we decided to determine whether bladder instillation with PAR-APs also induced up-regulation of iPLA2 in the mouse bladder mucosa.
Spec (whether) Regulation (regulation) of iPLA2 in urothelial cells
2) Confidence 0.22 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0 Pain Relevance 0
In this study, we have investigated the roles of TRPM8 and TRPA1 and the influence of iPLA2 on noxious cold sensitivities in naïve animals and after local administration of menthol, icilin and LPC.
Spec (investigated) Regulation (influence) of iPLA2
3) Confidence 0.16 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2822744 Disease Relevance 0.20 Pain Relevance 0.12
It is intriguing to speculate how iPLA2 could be redistributed to the leading edge of the cell exposed to a chemokinetic gradient and whether extracellular LPA signals originating from LPA GPCR through an inside-out mechanism could feed back into the regulation of iPLA2 and the cellular compass (Figure 5).
Regulation (regulation) of iPLA2 in edge
4) Confidence 0.15 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.05 Pain Relevance 0

General Comments

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