INT207100

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.13
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) endoplasmic reticulum (Ptpn1)
Anatomy Link Frequency
SH2 1
macrophages 1
blood 1
muscle tissue 1
muscle 1
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 98.76 Very High Very High Very High
Inflammatory response 12 98.66 Very High Very High Very High
cytokine 180 97.48 Very High Very High Very High
Inflammation 122 94.32 High High
agonist 200 93.52 High High
aspirin 2 88.96 High High
interstitial cystitis 1 85.04 High High
rheumatoid arthritis 1 62.80 Quite High
Hippocampus 12 61.92 Quite High
Thalamus 8 60.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 75 99.98 Very High Very High Very High
Insulin Resistance 353 99.04 Very High Very High Very High
INFLAMMATION 141 98.48 Very High Very High Very High
Obesity 289 98.12 Very High Very High Very High
Cognitive Disorder 10 97.92 Very High Very High Very High
Diabetes Mellitus 91 97.76 Very High Very High Very High
Hyperinsulinism 19 89.00 High High
Cancer 25 86.84 High High
Metastasis 1 86.08 High High
Weight Gain 28 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, transgenic overexpression of PTP1B in muscle decreased glucose uptake (29); meanwhile, ablation of PTP1B specifically in this tissue improved systemic insulin sensitivity when on a high-fat diet (30).
Gene_expression (overexpression) of PTP1B in muscle associated with targeted disruption
1) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.04 Pain Relevance 0.15
The effect produced by GW3965 on glucose uptake was parallel to a downregulation of socs3 and ptp1b gene expression and to the recovery of insulin phosphorylation of AKT (Fig. 7).
Gene_expression (expression) of ptp1b
2) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.40 Pain Relevance 0.26
Accordingly, our final goal was to investigate whether PTP1B deficiency confers protection against insulin resistance by IL-6.
Spec (whether) Gene_expression (deficiency) of PTP1B associated with insulin resistance
3) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.81 Pain Relevance 0.11
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Gene_expression (expression) of ptp1b in macrophages associated with metalloproteinase and cytokine
4) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.53 Pain Relevance 0.32
insulin resistance (6,7), we determined whether IL-6 treatment was modulating ptp1b expression.
Gene_expression (expression) of ptp1b associated with insulin resistance
5) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.42 Pain Relevance 0.07
However, IL-6 effects on PTP1B expression and activity were completely prevented by treatment with GW3965 or SP600125.


Gene_expression (expression) of PTP1B
6) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.45 Pain Relevance 0.04
Because IL-6 upregulated PTP1B expression, we decided to explore whether the lack of PTP1B might confer protection against IL-6–induced insulin resistance (Fig. 5A).
Gene_expression (expression) of PTP1B associated with insulin resistance
7) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.53 Pain Relevance 0.03
We did not detect changes in ptp1b expression by IL-6 treatment at 3 or 6 h (data not shown), but at 24 h, a significant increase on ptp1b mRNA accumulation and activity was observed (Fig. 4D and E).
Gene_expression (expression) of ptp1b
8) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.43 Pain Relevance 0.07
The overexpression of PTP1B in muscle tissue results in insulin resistance [29].
Gene_expression (overexpression) of PTP1B in muscle tissue associated with insulin resistance
9) Confidence 0.56 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.42 Pain Relevance 0
Another negative regulator of hematopoietic cell development and function is SHP-1 (SRC homology 2 (SH2)-containing tyrosine phosphatase 1), that is mainly expressed in hematopoietic and lymphoid cells [8].
Gene_expression (expressed) of tyrosine phosphatase 1 in SH2
10) Confidence 0.56 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.37 Pain Relevance 0.13
PTP1B deficiency and its heterozygote
Gene_expression (deficiency) of PTP1B
11) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.84 Pain Relevance 0.04
significantly reduce glucose concentrations in the blood, and PTP1B deficiency causes
Gene_expression (reduce) of PTP1B in blood
12) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.84 Pain Relevance 0.04
The present study has investigated the protein tyrosine phosphatase H1 (PTPH1) expression pattern in mouse brain and its impact on CNS functions.


Gene_expression (expression) of protein tyrosine phosphatase H1 in brain
13) Confidence 0.16 Published 2008 Journal Behav Brain Funct Section Abstract Doc Link PMC2531118 Disease Relevance 0.17 Pain Relevance 0.06
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of ptpn1 associated with inflammatory response
14) Confidence 0.15 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.88 Pain Relevance 0.35

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