INT207108

Context Info Confidence 0.40 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 1.61 Pain Relevance 0.77

plasma membrane (Pawr) nucleus (Pawr) enzyme binding (Pawr) cytoplasm (Pawr)

Anatomy Link Frequency muscle 1 peripheral nerves 1 Pawr (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 16 100.00 Inflammatory stimuli 30 88.56 Inflammatory response 36 81.32 agonist 8 79.80 Inflammation 222 78.08 c fibre 4 67.60 Pain 4 56.40 substance P 40 25.44 ischemia 8 5.00 ketamine 6 5.00

Disease Link Frequency Relevance Heat Overactive Bladder 20 99.74 Cancer 26 91.36 INFLAMMATION 282 88.24 Carcinoma 24 80.80 Coagulation Disorder 8 79.44 Cystitis 36 75.24 Adhesions 6 66.64 Pain 4 56.40 Urological Neuroanatomy 4 55.68 Injury 22 54.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [24].

Gene_expression (expressed) of PAR4 in muscle associated with overactive bladder

1) Confidence 0.40 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.71 Pain Relevance 0.33

In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [27].

Gene_expression (expressed) of PAR4 in peripheral nerves associated with overactive bladder

2) Confidence 0.33 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.46 Pain Relevance 0.12

PAR-AP – PAR1-, PAR2-, and PAR4-AP were synthesized at Molecular Biology Resource Facility, William K.

Gene_expression (synthesized) of PAR4

3) Confidence 0.31 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0 Pain Relevance 0

PAR1-AP, PAR2-AP, and PAR4-AP were synthesized at the Molecular Biology Resource Facility, William K.

Gene_expression (synthesized) of PAR4

4) Confidence 0.26 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.13 Pain Relevance 0.04

Indeed, we found that treatment with PAR1 and PAR4 antagonists did not affect implants size in our assay.

Gene_expression (antagonists) of PAR4 associated with antagonist

5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.31 Pain Relevance 0.08

PAR1 and PAR4 antagonists: The palmitoylated peptides: pal-RCLSSSAVANRS (PAR1 antagonist) and pal-SGRRYGHALR (PAR4 antagonist) were prepared by solid-phase peptide synthesis using in situ neutralization/HBTU by Hadar Biotec, Israel.

Gene_expression (antagonist) of PAR4 associated with antagonist

6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0.19

General Comments

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