INT207108

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.61
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pawr) nucleus (Pawr) enzyme binding (Pawr)
cytoplasm (Pawr)
Anatomy Link Frequency
muscle 1
peripheral nerves 1
Pawr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
Inflammatory stimuli 30 88.56 High High
Inflammatory response 36 81.32 Quite High
agonist 8 79.80 Quite High
Inflammation 222 78.08 Quite High
c fibre 4 67.60 Quite High
Pain 4 56.40 Quite High
substance P 40 25.44 Quite Low
ischemia 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 20 99.74 Very High Very High Very High
Cancer 26 91.36 High High
INFLAMMATION 282 88.24 High High
Carcinoma 24 80.80 Quite High
Coagulation Disorder 8 79.44 Quite High
Cystitis 36 75.24 Quite High
Adhesions 6 66.64 Quite High
Pain 4 56.40 Quite High
Urological Neuroanatomy 4 55.68 Quite High
Injury 22 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [24].
Gene_expression (expressed) of PAR4 in muscle associated with overactive bladder
1) Confidence 0.40 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.71 Pain Relevance 0.33
In addition to the urothelium, PAR1 and PAR2 are also expressed in mouse detrusor muscle, and PAR4 is expressed in mouse peripheral nerves and plexus cell bodies [27].
Gene_expression (expressed) of PAR4 in peripheral nerves associated with overactive bladder
2) Confidence 0.33 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.46 Pain Relevance 0.12
PAR-AP – PAR1-, PAR2-, and PAR4-AP were synthesized at Molecular Biology Resource Facility, William K.
Gene_expression (synthesized) of PAR4
3) Confidence 0.31 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0 Pain Relevance 0
PAR1-AP, PAR2-AP, and PAR4-AP were synthesized at the Molecular Biology Resource Facility, William K.
Gene_expression (synthesized) of PAR4
4) Confidence 0.26 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.13 Pain Relevance 0.04
Indeed, we found that treatment with PAR1 and PAR4 antagonists did not affect implants size in our assay.
Gene_expression (antagonists) of PAR4 associated with antagonist
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.31 Pain Relevance 0.08
PAR1 and PAR4 antagonists: The palmitoylated peptides: pal-RCLSSSAVANRS (PAR1 antagonist) and pal-SGRRYGHALR (PAR4 antagonist) were prepared by solid-phase peptide synthesis using in situ neutralization/HBTU by Hadar Biotec, Israel.
Gene_expression (antagonist) of PAR4 associated with antagonist
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0.19

General Comments

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