INT207111

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (Pawr) nucleus (Pawr) enzyme binding (Pawr)
Anatomy Link Frequency
urinary bladder 2
F2 (Mus musculus)
Pawr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 166 99.56 Very High Very High Very High
agonist 6 96.72 Very High Very High Very High
substance P 26 88.40 High High
Inflammatory response 29 73.44 Quite High
Inflammatory stimuli 25 54.32 Quite High
metalloproteinase 2 10.16 Low Low
ketamine 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
c fibre 3 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 214 99.56 Very High Very High Very High
Vasculitis 2 88.80 High High
Targeted Disruption 6 81.36 Quite High
Nociception 1 78.48 Quite High
Injury 16 73.60 Quite High
Cystitis 30 72.84 Quite High
Encephalitis 2 63.44 Quite High
Carcinoma 24 62.48 Quite High
Pressure And Volume Under Development 7 55.52 Quite High
Overactive Bladder 17 33.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
thrombin Positive_regulation (activator) of PAR4 in urinary bladder
1) Confidence 0.07 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.45 Pain Relevance 0.23
Indeed, in addition to PAR1, thrombin activates PAR4 [20] and type-II TGF?
thrombin Positive_regulation (activates) of PAR4
2) Confidence 0.04 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.51 Pain Relevance 0.16
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
thrombin Positive_regulation (activator) of PAR4 in urinary bladder
3) Confidence 0.04 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.43 Pain Relevance 0.25

General Comments

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