INT207116

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.16
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
urinary bladder 3
mast cell 2
F2 (Mus musculus)
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 245 99.56 Very High Very High Very High
agonist 49 90.96 High High
substance P 44 88.40 High High
neuropeptide release 6 82.44 Quite High
Nerve growth factor 42 79.64 Quite High
nociceptor 48 72.40 Quite High
Pain 23 61.44 Quite High
Calcitonin gene-related peptide 60 56.12 Quite High
Neuropeptide 36 55.60 Quite High
Inflammatory response 36 55.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 307 99.56 Very High Very High Very High
Nociception 64 92.92 High High
Injury 28 92.64 High High
Targeted Disruption 15 90.64 High High
Cystitis 38 82.12 Quite High
Carcinoma 24 71.76 Quite High
Vasculitis 2 70.72 Quite High
Pain 23 61.44 Quite High
Microphthalmia 23 58.68 Quite High
Pressure And Volume Under Development 10 54.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
thrombin Positive_regulation (activator) of PAR1 in urinary bladder
1) Confidence 0.12 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.32 Pain Relevance 0.11
However, when thrombin or trypsin, both of which activate PAR3 along with PAR1/4, were used in a number of different studies of functional expression, responses were seen in a significantly smaller proportion of neurones than those suggested by histological data for PAR3.
thrombin Positive_regulation (activate) of PAR1
2) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.11 Pain Relevance 0.20
For many of the functional studies we used thrombin, a protease which activates PAR1, 3 and 4 but not PAR2 receptors.
thrombin Neg (not) Positive_regulation (activates) of PAR1
3) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.21 Pain Relevance 0.15
PAR1, PAR3, and PAR4 are activated by thrombin, reviewed in [5,6], while PAR2 is not activated by thrombin but is activated by trypsin and mast cell tryptase [7-9].
thrombin Positive_regulation (activated) of PAR1 in mast cell
4) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.22 Pain Relevance 0.09
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
thrombin Positive_regulation (activator) of PAR1 in urinary bladder
5) Confidence 0.08 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.45 Pain Relevance 0.23
Regarding the difference of response between PAR1 -/- and PAR2 -/- mice, this may reflect a different role of the endogenous ligand since PAR1 is activated by thrombin, while PAR2 is activated by mast cell tryptase [23].
thrombin Positive_regulation (activated) of PAR1 in mast cell
6) Confidence 0.06 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.43 Pain Relevance 0.14
Although thrombin is a recognized physiological activator of PAR1 and PAR4, the endogenous enzymes responsible for activating PAR2 in urinary bladder are not known.
thrombin Positive_regulation (activator) of PAR1 in urinary bladder
7) Confidence 0.06 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.43 Pain Relevance 0.25

General Comments

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