INT20716

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Context Info
Confidence 0.46
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.70
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
hippocampus 2
trigeminal ganglion 1
lumen 1
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 33 100.00 Very High Very High Very High
agonist 22 100.00 Very High Very High Very High
Hippocampus 5 100.00 Very High Very High Very High
Neurotransmitter 7 99.96 Very High Very High Very High
Dopamine 73 99.32 Very High Very High Very High
Analgesic 5 99.20 Very High Very High Very High
trigeminal ganglion 34 98.36 Very High Very High Very High
gABA 50 96.56 Very High Very High Very High
monoamine 6 94.84 High High
GABAergic 21 92.48 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 15 99.40 Very High Very High Very High
Ganglion Cysts 46 97.92 Very High Very High Very High
Depression 12 91.80 High High
Peripheral Arterial Disease 3 91.52 High High
Neuropathic Pain 8 77.88 Quite High
Hypotension 1 73.44 Quite High
Pain 27 61.24 Quite High
Stroke 1 31.88 Quite Low
Generalized Anxiety Disorder 15 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M) on the release of [3H]-DA was abolished when the selective GABAB receptor antagonist CGP55845A (1 ?
Localization (receptor) of GABAB associated with dopamine and antagonist
1) Confidence 0.46 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.07
We conclude that post- and presynaptic GABAB receptors in area CA3 of the rat hippocampus couple to different effector mechanisms; postsynaptic GABAB receptors activate THA-sensitive K+ channels, and presynaptic GABAB receptors decrease neurotransmitter release through a THA-insensitive mechanism.
Localization (decrease) of GABAB in hippocampus associated with neurotransmitter and hippocampus
2) Confidence 0.43 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8096243 Disease Relevance 0.38 Pain Relevance 0.47
We conclude that post- and presynaptic GABAB receptors in area CA3 of the rat hippocampus couple to different effector mechanisms; postsynaptic GABAB receptors activate THA-sensitive K+ channels, and presynaptic GABAB receptors decrease neurotransmitter release through a THA-insensitive mechanism.
Localization (decrease) of GABAB in hippocampus associated with neurotransmitter and hippocampus
3) Confidence 0.43 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8096243 Disease Relevance 0.42 Pain Relevance 0.50
Presynaptic GABAB receptors are not tonically activated
Localization (receptors) of GABAB
4) Confidence 0.39 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.27 Pain Relevance 0.34
The present study investigates the effects of GABAA- and GABAB-receptor agonists and antagonists on gastric secretion after their i.c.v. administration to conscious pylorus-ligated rats and anaesthetized stomach lumen-perfused rats.
Localization (secretion) of GABAB-receptor in lumen associated with antagonist and agonist
5) Confidence 0.37 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2155808 Disease Relevance 0 Pain Relevance 0.10
GABAA and GABAB receptors are expressed in sensory neurons of the trigeminal ganglion
Localization (receptors) of GABAB in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
6) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.63 Pain Relevance 0.63

General Comments

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