INT207165

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 9.41
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DAK) lyase activity (DAK)
Anatomy Link Frequency
plasma 2
erythrocytes 1
brain 1
red blood cells 1
midbrain 1
DAK (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 783 99.66 Very High Very High Very High
Serotonin 62 96.20 Very High Very High Very High
midbrain 3 95.16 Very High Very High Very High
Inflammation 410 93.20 High High
cerebral cortex 3 84.64 Quite High
antidepressant 67 80.48 Quite High
cytokine 214 73.12 Quite High
imagery 5 71.92 Quite High
Angina 8 67.20 Quite High
sSRI 16 55.68 Quite High
Disease Link Frequency Relevance Heat
Obesity 72 99.98 Very High Very High Very High
Post-partum Depression 134 99.66 Very High Very High Very High
Disease 158 99.60 Very High Very High Very High
Depression 706 98.32 Very High Very High Very High
Mental Disorders 36 98.08 Very High Very High Very High
Increased Venous Pressure Under Development 28 98.00 Very High Very High Very High
Manic Depressive Disorder 12 97.84 Very High Very High Very High
Urological Neuroanatomy 10 97.08 Very High Very High Very High
Suicidal Behaviour 34 96.68 Very High Very High Very High
Cancer 73 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LC-PUFAS, DHA and AA can be synthesized from ALA and LA, although the activity of conversion is low in humans [2,4,5].
Gene_expression (synthesized) of DHA
1) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2707376 Disease Relevance 0.22 Pain Relevance 0
The premature babies, in particular, born during the last trimester of pregnancy have been shown to have low levels of DHA in the blood; this has been correlated with their abnormal eye and brain functions as measured by electroretinogram, cortical visual-evoked potential, and behavioral testing of visual acuity [15,16]
Gene_expression (levels) of DHA in brain
2) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2707376 Disease Relevance 0.14 Pain Relevance 0.04
CK7 (OV-TL 12/30, 1:60, DAKO), CK20 (KS 20.8, 1:20, DAKO), EMA (E29, 1:50, DAKO), CEAm (12-140-10, 1:50, NOVOCASTRA), CEAp (Rabbit anti-human polyclonal antibody, 1:4000, DAKO), TTF-1 (8G7G3/1 1:40, ZYMED), Chromogranin (DAK-A3, 1:20, DAKO) and S-100 (Rabbit anti-human polyclonal antibody, 1:1000, DAKO) were negative.
Neg (negative) Gene_expression (negative) of DAK-A3
3) Confidence 0.06 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2630932 Disease Relevance 0.44 Pain Relevance 0
The premature babies, in particular, born during the last trimester of pregnancy have been shown to have low levels of DHA in the blood; this has been correlated with their abnormal eye and brain functions as measured by electroretinogram, cortical visual-evoked potential, and behavioral testing of visual acuity [15,16]
Gene_expression (levels) of DHA in eye
4) Confidence 0.03 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2707376 Disease Relevance 0.14 Pain Relevance 0.04
Studies of erythrocyte, serum, plasma, or adipose tissue levels of DHA and other n-3 PUFAs have found similar results [69–79]; findings that have been supported by subsequent meta-analysis [80].
Gene_expression (levels) of DHA in plasma associated with obesity
5) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.77 Pain Relevance 0.19
This intervention increased the levels of EPA and DHA in the red blood cells in the actively treated group from 3.5±0.1% to 7.6±0.3%.
Gene_expression (levels) of DHA in red blood cells
6) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.53 Pain Relevance 0
In contrast to fish, the natural source of EPA and DHA, ethyl ester preparations of EPA +/and DHA contain no mercury.
Gene_expression (source) of DHA
7) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.37 Pain Relevance 0.06
It has been argued that the initial levels of EPA and DHA in this study were high enough to obscure any treatment effect (Leaf et al 2005), an argument consistent with the concept of the omega-3 index (Harris and von Schacky 2004).
Gene_expression (levels) of DHA in Leaf
8) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.40 Pain Relevance 0
When ingested by humans in the chemical form of phospholipids or triglycerides, peak levels of EPA and DHA in plasma are higher than when ingested as ethyl esters (Beckermann et al 1990; Visioli et al 2003).
Gene_expression (levels) of DHA in plasma
9) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.17 Pain Relevance 0
In contrast to fish, the natural source of EPA and DHA, ethyl ester preparations of EPA +/and DHA contain no mercury.
Gene_expression (source) of DHA
10) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.38 Pain Relevance 0.07
Similarly, rats fed an n-3 PUFA-deficient diet from birth, which produced brain DHA levels 61% lower than controls as a result of inadequate accumulation during postnatal development, exhibited decreased midbrain expression of tryptophan hydroxylase, the enzyme that synthesizes serotonin, and increased serotonin turnover in the prefrontal cortex [156].
Gene_expression (produced) of DHA in midbrain associated with midbrain and serotonin
11) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.33 Pain Relevance 0.37
Similarly, women who later developed postpartum depression had lower serum DHA levels after delivery than those who did not develop depressive symptoms [55], although other studies did not find such a relationship [56–58].
Gene_expression (levels) of DHA associated with depression and post-partum depression
12) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.89 Pain Relevance 0.35
DHA stimulation of stem cell neuronal differentiation has been observed in other systems via modulation of cell cycle and basic helix–loop–helix transcription factors [150].While glucose utilization is reduced in AD, DHA increased the expression of a major brain endothelial cell glucose transporter [151].DHA improves the age-impaired coupling of blood flow to glucose utilization in aged monkeys [152].
Gene_expression (expression) of DHA in blood associated with disease
13) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 1.01 Pain Relevance 0.07
Although slight differences in biological activity exist between EPA and DHA, both exert a number of positive actions against atherosclerosis and its complications.
Gene_expression (exist) of DHA associated with increased venous pressure under development
14) Confidence 0.01 Published 2006 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC1993981 Disease Relevance 0.25 Pain Relevance 0.04
A listing of sources of EPA/DHA that are tested for contaminants can be seen in Additional file 1.


Gene_expression (sources) of DHA
15) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 0.72 Pain Relevance 0.45
For example, populations with higher levels of EPA and DHA in their diets had lower levels of major depression, bipolar disorder, and future suicide risk [60-62].
Gene_expression (levels) of DHA associated with suicidal behaviour, manic depressive disorder and depression
16) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 1.25 Pain Relevance 0.26
Fortunately, there are a alternative sources of EPA and DHA that are tested for contaminants and are contaminant free.
Gene_expression (sources) of DHA
17) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 0.72 Pain Relevance 0.39
However, pregnant or breastfeeding women often need to limit the amount of fish they eat, the prime source of EPA and DHA, because of contaminants in seafood.
Gene_expression (source) of DHA
18) Confidence 0.01 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 0.69 Pain Relevance 0.36
Thus changes in levels of EPA and DHA in erythrocytes and leukocytes appear to correlate during n-3 LCPUFA supplementation [34,35], although the rate of incorporation between these cell types is different in the first 6 to 12 weeks of supplementation.
Gene_expression (levels) of DHA in leukocytes
19) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0
Thus changes in levels of EPA and DHA in erythrocytes and leukocytes appear to correlate during n-3 LCPUFA supplementation [34,35], although the rate of incorporation between these cell types is different in the first 6 to 12 weeks of supplementation.
Gene_expression (levels) of DHA in erythrocytes
20) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox