INT207192

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 32 95.24 Very High Very High Very High
Hippocampus 19 70.44 Quite High
depression 10 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 69 100.00 Very High Very High Very High
Targeted Disruption 26 76.56 Quite High
Weight Gain 1 6.32 Low Low
Depression 14 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Affective Disorder 3 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Depressive Disorder 1 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the chronic treatment with imipramine completely abolished the stimulating effect of chronic social stress on CRE/CREB-directed transcription and resulted in levels similar to control.


Negative_regulation (abolished) of Transcription (transcription) of CREB associated with stress
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.58 Pain Relevance 0.11

General Comments

This test has worked.

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