INT207194

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 99.00 Very High Very High Very High
addiction 5 96.32 Very High Very High Very High
antidepressant 36 90.24 High High
Dopamine 6 74.64 Quite High
cocaine 1 60.72 Quite High
antagonist 3 33.08 Quite Low
Nucleus accumbens 5 30.40 Quite Low
Eae 7 25.68 Quite Low
depression 13 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 98.48 Very High Very High Very High
Stress 80 97.84 Very High Very High Very High
Drug Dependence 4 96.72 Very High Very High Very High
Shock 5 91.04 High High
Targeted Disruption 50 50.00 Quite Low
Anxiety Disorder 12 49.20 Quite Low
Depressive Disorder 1 41.20 Quite Low
Depression 17 5.00 Very Low Very Low Very Low
Convulsion 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, changes in the transcriptional activity of CREB and of its gene product BDNF depend not only on the brain region but also on the type of stress and its duration.
Regulation (depend) of Regulation (changes) of CREB in brain associated with stress
1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.92 Pain Relevance 0.35
Further detailed examination of other types of memory is necessary in order to fully delineate memory systems critically dependent on CREB/ICER regulation.


Regulation (dependent) of Regulation (regulation) of CREB
2) Confidence 0.25 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.17 Pain Relevance 0.11

General Comments

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