INT207195

Context Info Confidence 0.25 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.92 Pain Relevance 0.35

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)

Anatomy Link Frequency brain 2 Bdnf (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 19 99.00 antidepressant 32 90.24 Dopamine 1 74.64 depression 10 5.00 monoamine 4 5.00 Locus ceruleus 3 5.00 sSRI 3 5.00 Somatostatin 3 5.00 Central nervous system 1 5.00 fluoxetine 1 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1 98.48 Stress 69 97.84 Shock 2 91.04 Targeted Disruption 26 50.00 Depressive Disorder 1 41.20 Depression 14 5.00 Body Weight 5 5.00 Affective Disorder 3 5.00 Aggression 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, changes in the transcriptional activity of CREB and of its gene product BDNF depend not only on the brain region but also on the type of stress and its duration.

Regulation (depend) of Regulation (changes) of BDNF in brain associated with stress

1) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.92 Pain Relevance 0.35

General Comments

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