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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
dorsal 2
central nervous system 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 100.00 Very High Very High Very High
fluoxetine 31 96.96 Very High Very High Very High
depression 95 94.44 High High
Glutamate 8 92.48 High High
Nucleus accumbens 18 92.24 High High
addiction 36 91.24 High High
bDMF 32 83.44 Quite High
cocaine 8 80.04 Quite High
Hippocampus 45 73.12 Quite High
monoamine 7 72.96 Quite High
Disease Link Frequency Relevance Heat
Stress 79 99.98 Very High Very High Very High
Depression 106 94.44 High High
Drug Dependence 7 59.20 Quite High
Affective Disorder 5 54.32 Quite High
Targeted Disruption 66 50.00 Quite Low
Recurrence 4 30.32 Quite Low
Disease 5 29.28 Quite Low
INFLAMMATION 1 25.28 Quite Low
Cancer 2 23.20 Low Low
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the central nervous system CREB action was first described for the adrenergic system where generation of cAMP by ?
Positive_regulation (central nervous system) of Transcription (described) of CREB in central nervous system associated with central nervous system
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.23 Pain Relevance 0.36
A key mechanism for regulating gene expression is through nuclear induction of the transcription factor CREB, implicated also in various affective states, learning and memory.
Positive_regulation (induction) of Transcription (transcription) of CREB
2) Confidence 0.49 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.15
Among the mRNA targets of miR-103 was also the transcription factor CREB1 gene, which binds as a homodimer to cAMP responsive elements within the DNA sequence [39].
Positive_regulation (targets) of Transcription (transcription) of CREB1 gene
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
Chronic Citalopram treatment inhibited the CREB phosporylation in female rats [158] and prevented the chronic stress induced CREB mRNA expression in dorsal raphae nucleus of rat [1] and a similar effect was observed with fluoxetine [317].
Positive_regulation (induced) of Transcription (expression) of CREB in dorsal associated with stress and fluoxetine
4) Confidence 0.30 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.41 Pain Relevance 0.58

General Comments

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