INT207203

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.73
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
neuronal 1
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 36 99.60 Very High Very High Very High
cytokine 49 99.18 Very High Very High Very High
Dopamine 191 97.48 Very High Very High Very High
Hippocampus 40 90.72 High High
Locus ceruleus 3 77.68 Quite High
Raphe 1 76.32 Quite High
headache 4 75.20 Quite High
agonist 72 69.92 Quite High
Neurotransmitter 30 66.84 Quite High
Serotonin 4 61.68 Quite High
Disease Link Frequency Relevance Heat
Advanced Or Metastatic Breast Cancer 84 100.00 Very High Very High Very High
Apoptosis 23 98.44 Very High Very High Very High
Disease 287 96.72 Very High Very High Very High
Stress 87 95.68 Very High Very High Very High
Hyperlipidemia 13 94.72 High High
Death 27 94.44 High High
Toxicity 19 81.52 Quite High
Lung Cancer 1 79.52 Quite High
Headache 4 75.20 Quite High
Vomiting 13 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and PI3K/AKT signaling pathways and was evaluated at ASCO 2008 in a phase II study in MBC patients previously treated with an anthracycline and a taxane containing regimen.[66] The monotherapy was well tolerated but it was found to have no activity in this pretreated population of MBC patients.
Transcription (tolerated) of AKT associated with advanced or metastatic breast cancer
1) Confidence 0.67 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.25 Pain Relevance 0.08
The demonstration that PTEN/Akt mRNA expression is modulated in response to different apoptotic inducers [7] strongly suggests the association of this pathway with neuronal survival and death.
Transcription (expression) of Akt in neuronal associated with apoptosis and death
2) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.35 Pain Relevance 0.32
, PKB/AKT, ERK, and JNK, as well as the transcriptional activity of CREB.
Transcription (activity) of AKT
3) Confidence 0.39 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.54 Pain Relevance 0.05
, PKB/AKT, ERK, and JNK, as well as the transcriptional activity of CREB.
Transcription (activity) of PKB
4) Confidence 0.39 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.54 Pain Relevance 0.05
The effects of signalling pathways involving adenylate cyclase and cAMP, Ca2+ and different kinases on CREB/CREB-regulated gene transcription are well established[30].
Transcription (transcription) of kinases
5) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.20
Circadian clocks in mammalian tissues generate molecular circadian rhythms through coupled transcription/translation feedback loops in which the positive gene elements Clock and Bmal1 interact with the negative gene elements Period (Per) 1 and 2, and Cryptochrome (Cry) 1 and 2, and in which casein kinases, CKI?
Transcription (transcription) of kinases
6) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.27
of cytokine signaling by targeting protein tyrosine kinases or transcription
Transcription (transcription) of kinases associated with cytokine
7) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.33 Pain Relevance 0.14

General Comments

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