INT207204

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
neuronal 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 23 99.72 Very High Very High Very High
Dopamine 116 97.48 Very High Very High Very High
Hippocampus 20 90.72 High High
Locus ceruleus 3 77.68 Quite High
Raphe 1 76.32 Quite High
agonist 44 69.92 Quite High
Serotonin 4 62.72 Quite High
Central nervous system 48 55.60 Quite High
midbrain 15 53.64 Quite High
Inflammation 35 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 11 98.96 Very High Very High Very High
Stress 71 95.68 Very High Very High Very High
Death 13 94.96 High High
Disease 65 93.76 High High
Toxicity 1 81.52 Quite High
Multiple Sclerosis 36 74.24 Quite High
Body Weight 5 57.92 Quite High
Targeted Disruption 38 50.96 Quite High
INFLAMMATION 41 50.00 Quite Low
Injury 10 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The demonstration that PTEN/Akt mRNA expression is modulated in response to different apoptotic inducers [7] strongly suggests the association of this pathway with neuronal survival and death.
Regulation (modulated) of Transcription (expression) of Akt in neuronal associated with apoptosis and death
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.35 Pain Relevance 0.32
The effects of signalling pathways involving adenylate cyclase and cAMP, Ca2+ and different kinases on CREB/CREB-regulated gene transcription are well established[30].
Regulation (regulated) of Transcription (transcription) of kinases
2) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.20
of cytokine signaling by targeting protein tyrosine kinases or transcription
Regulation (targeting) of Transcription (transcription) of kinases associated with cytokine
3) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.34 Pain Relevance 0.14

General Comments

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