INT207211

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.35
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Crem) DNA binding (Creb1, Crem) mitochondrion (Creb1)
transcription factor binding (Creb1)
Creb1 (Mus musculus)
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 3 95.28 Very High Very High Very High
monoamine 4 81.20 Quite High
antidepressant 40 79.48 Quite High
depression 16 76.84 Quite High
addiction 9 50.32 Quite High
Eae 14 22.16 Low Low
Hippocampus 29 14.72 Low Low
Nucleus accumbens 10 5.28 Low Low
Dopamine 11 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 16 98.96 Very High Very High Very High
Drug Induced Neurotoxicity 2 98.32 Very High Very High Very High
Injury 2 97.72 Very High Very High Very High
Death 4 83.68 Quite High
Depression 20 76.84 Quite High
Affective Disorder 3 62.56 Quite High
Stress 91 52.08 Quite High
Targeted Disruption 74 50.00 Quite Low
Disease 3 34.76 Quite Low
Anxiety Disorder 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All ICER isoforms homodimerize or heterodimerize with other members of the CREB/CREM/ATF-1 family [12, 13, 24, 25].


CREB Binding (heterodimerize) of ICER isoforms homodimerize
1) Confidence 0.30 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0
ICER may interfere with the pro-survival action of CREB and contribute to neurodegeneration from neurotoxicity, trauma, and trophic deprivation or disorder [62].
CREB Binding (interfere) of ICER associated with drug induced neurotoxicity and injury
2) Confidence 0.23 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 1.04 Pain Relevance 0
CREB belongs to the family of basic leucine zipper transcription factors and modulates gene transcription by binding to the cAMP responsive element (CRE) in the promoter regions of various genes[9].
CREB Binding (binding) of cAMP responsive element
3) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.31 Pain Relevance 0.36

General Comments

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